Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

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dc.authoridGul, Mustafa/0000-0002-0042-890X
dc.contributor.authorGursul, Cebrail
dc.contributor.authorAkdemir, Fazile Nur Ekinci
dc.contributor.authorAkkoyun, Turan
dc.contributor.authorCan, Ismail
dc.contributor.authorGul, Mustafa
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-12-24T19:30:59Z
dc.date.available2024-12-24T19:30:59Z
dc.date.issued2016
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p<0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p<0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p<0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.
dc.description.sponsorshipAtaturk University
dc.description.sponsorshipThe authors are grateful to the Research Fund of Ataturk University for financial support.
dc.identifier.doi10.3109/14756366.2016.1167050
dc.identifier.endpage61
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.pmid27052452
dc.identifier.scopus2-s2.0-84964056757
dc.identifier.scopusqualityQ1
dc.identifier.startpage56
dc.identifier.urihttps://doi.org/10.3109/14756366.2016.1167050
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7758
dc.identifier.volume31
dc.identifier.wosWOS:000389344900007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAntioxidant enzymes
dc.subjectischemia/reperfusion injury
dc.subjectNaringin
dc.subjectreactive oxygen species
dc.subjectskeletal muscle
dc.titleProtective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats
dc.typeArticle

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