Expression and localization of insulin-like growth factor gene family members in the caprine ovarian and uterine tissues during different pregnancy stages

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dc.authoridTURGUT, Ali Osman/0000-0001-6863-0939
dc.contributor.authorAgaoglu, Ozgecan Korkmaz
dc.contributor.authorAgaoglu, Ali Reha
dc.contributor.authorOzmen, Ozlem
dc.contributor.authorTurgut, Ali Osman
dc.contributor.authorSaatci, Mustafa
dc.date.accessioned2024-12-24T19:24:50Z
dc.date.available2024-12-24T19:24:50Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractGoats are of significant economic importance, yet our knowledge of the molecular pathways involved in their pregnancy remains limited. This study aims to investigate the role of IGFs in uterine and ovarian cellular events during pregnancy in goats. Forty-two Hair Goats were examined, including four pregnancy groups representing embryo- positive (G1, n=7), early (G2, n=7), mid (G3, n=7), and late pregnancy (G4, n=7), as well as two luteal stage groups representing early (G5, n=7) and late (G6, n=7) phases. Uterine and ovarian tissues were collected, and RT-qPCR and immunohistochemistry were performed to evaluate IGF expression. The results showed that IGF1 and IGF2 expressions were significantly higher in G1 than in other pregnancy and control groups (p < 0.05). Additionally, IGFBP1 expression was higher in G2 than in G1 and G4 (p < 0.05), and IGFBP3 expression was higher in G4 than in any other pregnancy stage (p < 0.05). However, no statistically significant differences were observed in the expression levels of IGFBP4 and IGFBP6 between any of the groups. Finally, IGFBP5 expression was significantly higher in G1, G3, and G4 compared to G2 (p < 0.05). Overall, the dynamic changes observed in the expression of the IGF gene family during different stages of pregnancy highlight the crucial role of IGFs in regulating pregnancy in goats.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [117O613]
dc.description.sponsorshipThis study was financed by the Scientific and Technological Research Council of Turkey (TUBITAK; Project No.117O613).
dc.identifier.doi10.1007/s11250-023-03719-9
dc.identifier.issn0049-4747
dc.identifier.issn1573-7438
dc.identifier.issue5
dc.identifier.pmid37723411
dc.identifier.scopus2-s2.0-85171666652
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11250-023-03719-9
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6137
dc.identifier.volume55
dc.identifier.wosWOS:001188392100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTropical Animal Health and Production
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectIGF genes
dc.subjectPregnancy
dc.subjectGoat
dc.subjectExpression
dc.subjectRT-qPCR
dc.titleExpression and localization of insulin-like growth factor gene family members in the caprine ovarian and uterine tissues during different pregnancy stages
dc.typeArticle

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