Analysis and dynamical behavior of fractional-order cancer model with vaccine strategy
[ X ]
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In recent year, the world has witnessed the arrival of deadly diseases like cancer over all the global levels. To fight back this disease or control the spread, mankind relies on modeling and medicine to control, cure, and behavior of the cancer diseases. We developed the fractional-order immunotherapy bladder cancer model and used the BCG vaccine for treatment by using the Caputo fractional derivative operator phi e(0,1]. A mathematical model has four variables B,E, T-i, T-u which represent the vaccine for the immune system, effector cells, total population of affected, and unaffected cells, respectively. In this model, we have two cases according to the growth rate of cells. The fractional-order system is stable in both cases and gives the solution infeasible region for uniqueness, positivity, and boundedness to illustrate the treatment of cancer. The effect of fractional parameter on our obtained solutions is presented, and a comparison is made with the classical ordinary derivative operator. It is worthy to observe that fractional derivatives show significant changes and memory effects as compared with ordinary derivatives to control the disease at the initial stage to overcome the risk of living with cancer.
Açıklama
Anahtar Kelimeler
superficial bladder cancer, immunotherapy, vaccine, stability, Caputo derivative, numerical simulation
Kaynak
Mathematical Methods in The Applied Sciences
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
43
Sayı
7
