Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn (II), and Ru(III) complexes of pyrazolone-based Schiff base ligand

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dc.authoridAY, BURAK/0000-0001-7055-8139
dc.authoridcakmak, resit/0000-0003-0401-7419
dc.authoridAkkoc, Senem/0000-0002-1260-9425
dc.authoridBasaran, Eyup/0000-0002-7840-5919
dc.authoridBoga, Mehmet/0000-0003-4163-9962
dc.authoridcinar, ercan/0000-0003-0419-7798
dc.contributor.authorCakmak, Resit
dc.contributor.authorAy, Burak
dc.contributor.authorCinar, Ercan
dc.contributor.authorBasaran, Eyup
dc.contributor.authorAkkoc, Senem
dc.contributor.authorBoga, Mehmet
dc.contributor.authorTas, Esref
dc.date.accessioned2024-12-24T19:27:30Z
dc.date.available2024-12-24T19:27:30Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractMetal-based drugs have gained significant importance in medicine in recent years. In this research, a series of new Co(II), Ni (II), Cu (II), Zn(II), and Ru(III) complexes of a Schiff base ligand, (1,5-dimethyl-4-((1-(3-nitrophenyl)ethylidene) amino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one), were prepared for the first time in excellent yields, and characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, ICP-OES, and thermal analysis. The in vitro antiproliferative, anticholinesterase, and antioxidant properties of complexes 1-5 were evaluated. The cytotoxic effects of complexes 1-5 on the viability of colon cancer (DLD-1), breast cancer (MDA-MB-231), and healthy lung (Wl-38) cell lines were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method in vitro. The anticancer activities of the ligand and its metal complexes were lower than those of the reference drug, cisplatin. In anticholinesterase activity studies, complex 4 (88.46 +/- 0.45% inhibition) in butyrylcholinesterase (BChE) assay showed a higher inhibitory effect than the standard compound galanthamine with 78.14 +/- 0.55% inhibition. In antioxidant assays, some complexes showed higher antioxidant activities than standard antioxidant butylated hydroxytoluene (BHT). Among the prepared complexes, complex (4) (IC50=5.91 +/- 0.17 mu M) in ABTS assay showed the highest antioxidant activity compared to BHT (IC50=16.19 +/- 0.17 mu M). Also, this complex (IC50=10.17 +/- 0.36 mu M) showed the best antioxidant activity in CUPRAC assay compared to BHT (IC50=39.37 +/- 0.12 mu M).
dc.description.sponsorshipBatman University; Suleyman Demirel University Research Fund [TSG-2021-8458]
dc.description.sponsorshipThe authors would like to thank Batman University, Cukurova University, and Suleyman Demirel University for their laboratory support in this study. SA would like to thank the Suleyman Demirel University Research Fund for financial support (project number TSG-2021-8458) .
dc.identifier.doi10.1016/j.molstruc.2023.136225
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85165317491
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.136225
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6675
dc.identifier.volume1292
dc.identifier.wosWOS:001149564400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectMetal complex
dc.subjectAnticancer agent
dc.subjectEnzyme inhibitory activity
dc.subjectAntioxidant activity
dc.titleSynthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn (II), and Ru(III) complexes of pyrazolone-based Schiff base ligand
dc.typeArticle

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