Advanced-designed Ru(II) complexes containing phosphinite ligands derived from chiral amino alcohols: Electrochemical behavior, DFT calculations, and biological activity

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dc.authoridISIK, UGUR/0000-0003-1010-9563
dc.contributor.authorMeric, Nermin
dc.contributor.authorIsik, Ugur
dc.contributor.authorDauletbakov, Anuar
dc.contributor.authorZolotareva, Darya
dc.contributor.authorZazybin, Alexey
dc.contributor.authorSever, Mehmet Serif
dc.contributor.authorOkumus, Veysi
dc.date.accessioned2024-12-24T19:27:28Z
dc.date.available2024-12-24T19:27:28Z
dc.date.issued2025
dc.departmentSiirt Üniversitesi
dc.description.abstractWe report two phosphinite ligands derived from chiral amino alcohols, and their complexes with ruthenium(II). These compounds were characterized by spectroscopic methods. Then, antimicrobial, antioxidant, and DNA binding activities of the chiral Ru(II)-phosphinite complexes were tested. Complex (1R)-2-{benzyl[(1S)-1(naphthalen-1-yl)ethyl]amino}-1-phenylethyl diphenylphos- phinito[dichloro(eta 6-p-cymene)ruthenium(II)], 7 showed both the highest radical scavenging activity (90.93 +/- 0.98 %) and the highest metal chelating activity (65.45 +/- 1.46 %) at 200.0 mg l-1 concentration. In addition, all of complexes had different rates of binding activity to calf thymus DNA (CT-DNA). Moreover, extensive theoretical and experimental investigations were conducted to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the ruthenium complexes, as well as their electrochemical characteristics.
dc.description.sponsorshipMinister of Science and Higher Educa-tion of the Republic of Kazakhstan [AP19578051]; Dicle University [FEN.24.020]
dc.description.sponsorshipThe research was funded by Minister of Science and Higher Educa-tion of the Republic of Kazakhstan (Grant No: AP19578051) . Partial supports of this work by Dicle University (Project number: FEN.24.020) is gratefully acknowledged.
dc.identifier.doi10.1016/j.jorganchem.2024.123410
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85207257912
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2024.123410
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6639
dc.identifier.volume1023
dc.identifier.wosWOS:001345791700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectChiral amino alcohols
dc.subjectRuthenium complexes
dc.subjectBiological properties
dc.subjectDFT calculations
dc.subjectElectrochemical behavior
dc.titleAdvanced-designed Ru(II) complexes containing phosphinite ligands derived from chiral amino alcohols: Electrochemical behavior, DFT calculations, and biological activity
dc.typeArticle

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