Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation

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dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.authoridAydemir, Murat/0000-0002-4238-5012
dc.authoridKILIC, Ahmet/0000-0001-9073-4339
dc.contributor.authorKilic, Ahmet
dc.contributor.authorBalci, Tubba Ersayan
dc.contributor.authorArslan, Nevin
dc.contributor.authorAydemir, Murat
dc.contributor.authorDurap, Feyyaz
dc.contributor.authorOkumu, Veysi
dc.contributor.authorTekin, Recep
dc.date.accessioned2024-12-24T19:24:07Z
dc.date.available2024-12-24T19:24:07Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractTwo cis-1,2-diol-type chiral ligands (T-1 and T-2) and their tri-coordinated chiral dioxaborinane (T(1-2)B(1-2)) and four-coordinated chiral dioxaborinane adducts with 4-tert-butyl pyridine sustained by N -> B dative bonds (T(1-2)B(1-2)-N) were synthesized and characterized by various spectroscopic techniques such as NMR (H-1, C-13, and B-11), FT-IR and UV-Vis spectroscopy, LC-MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.
dc.description.sponsorshipResearch Fund of Harran University (HUBAP Projects) Sanliurfa, Turkey [19023]
dc.description.sponsorshipWe acknowledge gratefully the financial support from Research Fund of Harran University (HUBAP Projects No: 19023) Sanliurfa, Turkey.
dc.identifier.doi10.1002/aoc.5835
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85085991294
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/aoc.5835
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5842
dc.identifier.volume34
dc.identifier.wosWOS:000537708200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectasymmetric transfer hydrogenation
dc.subjectbiological activitieschiral dioxaborinanesCis-1
dc.subject2-diol-type chiral ligands
dc.titleSynthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation
dc.typeArticle

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