Predictive Value of Plasma Zonulin Levels during Early Gestational Weeks in Gestational Diabetes Mellitus

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dc.contributor.authorCelal Cengiz
dc.contributor.authorLebriz Hale Aktün Tamer
dc.contributor.authorVolkan Ülker
dc.contributor.authorMustafa Cengiz
dc.contributor.authorİsa Aykut Özdemir
dc.date.accessioned2025-01-27T10:05:16Z
dc.date.available2025-01-27T10:05:16Z
dc.date.issued2024-12-25
dc.departmentFakülteler, Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümü
dc.description.abstractObjective: This study aimed to determine the impact and predictive utility of serum zonulin levels measured between 11-14 weeks of gestation and 75-g oral glucose tolerance test (OGTT) testing between 24-28 weeks of gestation in predicting patients diagnosed with gestational diabetes mellitus (GDM). Methods: The study included 209 pregnant women at 11-14 weeks of gestation. Among the pregnant women who presented to the Obstetrics and Gynecology Outpatient Department of İstanbul Medipol Mega Hospital, those who could not be reached due to the covid pandemic (69), aborted (4), diagnosed with chromosomal abnormalities in the fetus (3), and those who withdrew from the study (4) were excluded from the study. The study group included 48 pregnant women diagnosed with GDM at 24-28 weeks of gestation. On the other hand, the control group was formed by randomly selecting 40 pregnant women from 81 pregnant women who were not diagnosed with GDM due to the lack of a kit using a computer-based program. GDM was diagnosed using an OGTT performed between 24 and 28 weeks of gestation according to the International Association of Diabetes and Pregnancy Study Groups criteria. Plasma zonulin levels were measured using enzyme-linked immunosorbent assay. Results: When zonulin (ng/mL) and body mass index (BMI) (kg/m2) values were compared between the study and control groups, a significant correlation was found between zonulin (35.77±8.79 (ng/mL), 29.76±6.96 (ng/mL), p=0.01) and BMI (kg/m2) (26.02±2.39, 24.78±2.7 (kg/m2), p=0.032). In addition, a correlation analysis showed a significant positive correlation between plasma zonulin level and first-hour OGTT. Conclusion: The findings of our research indicate that zonulin has the potential to function as a non-invasive biomarker of GDM development. More extensive research is required on this topic.
dc.identifier.citationCengiz, C., Tamer, L. H. A., Ülker, V., Cengiz, M., & Özdemir, İ. A. (2024). Predictive Value of Plasma Zonulin Levels during Early Gestational Weeks in Gestational Diabetes Mellitus. Med J Bakirkoy, 20(4), 302-307.
dc.identifier.doi10.4274/bmj.galenos.2024.2023.8-17
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85214581070
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2024.2023.8-17
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8464
dc.identifier.volume20
dc.identifier.wosWOS:001383107300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.institutionauthorÖzdemir, İsa Aykut
dc.publisherGalenos Yayinevi
dc.relation.ispartofBakirkoy Tip Dergisi / Medical Journal of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBody mass index
dc.subjectgestational diabetes mellitus
dc.subjectzonulin
dc.titlePredictive Value of Plasma Zonulin Levels during Early Gestational Weeks in Gestational Diabetes Mellitus
dc.typejournal-article
oaire.citation.issue4
oaire.citation.volume20

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