Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats

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dc.authoridAlayunt, Naci Omer/0000-0003-2215-0934
dc.authoridTas, Fatih/0000-0001-9817-4241
dc.contributor.authorAlayunt, Naci Omer
dc.contributor.authorParlak, Akif Evren
dc.contributor.authorTurkoglu, Semra
dc.contributor.authorTas, Fatih
dc.date.accessioned2024-12-24T19:30:06Z
dc.date.available2024-12-24T19:30:06Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThis research aimed to explore the protective and therapeutic properties of safranal in mitigating inflammation and oxidative stress induced by elevated acetaminophen (APAP) doses in a rat model. The protective and therapeutic effects of safranal were determined by histopathologically and examining some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), glutathione, glutathione peroxidase, catalase, malondialdehyde, interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta. Male Wistar-Albino rats were subject to random allocation, forming five groups, each comprising seven rats (n = 7) in the study. Group 1 was the control group. APAP was administered in Group 2 to induce hepatotoxicity. Rats in Groups 3, 4, and 5 received intraperitoneal injections of safranal at doses of 0.025, 0.05, and 0.1 mL/kg/day for 14 days, respectively. On the 15th day, to induce APAP-induced hepatotoxicity, four groups (Groups 2, 3, 4, and 5) acquired a single intraperitoneal injection of 600 mg/kg APAP. The presence of APAP-induced hepatotoxic effect was proven by elevated AST and ALT levels, which are typical biomarkers of liver function in addition to the demonstration of histopathological changes. The findings suggest that pre-treatment with safranal may offer a protective effect against hepatotoxicity by attenuating oxidative stress and the inflammatory response.
dc.identifier.doi10.1515/chem-2024-0029
dc.identifier.issn2391-5420
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85192857351
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1515/chem-2024-0029
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7391
dc.identifier.volume22
dc.identifier.wosWOS:001214445900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDe Gruyter Poland Sp Z O O
dc.relation.ispartofOpen Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectantioxidant
dc.subjectinflammation
dc.subjectliver injury
dc.subjectoxidative stress
dc.subjectsafranal
dc.titleHepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
dc.typeArticle

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