Effects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer

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dc.authoridBAHCIVAN, Emre/0000-0002-4415-1738
dc.authoridYazar, Enver/0000-0002-6508-7245
dc.authoridOzdemir, Ozgur/0000-0002-1595-0557
dc.contributor.authorEr, A.
dc.contributor.authorOzdemir, O.
dc.contributor.authorCoskun, D.
dc.contributor.authorDik, B.
dc.contributor.authorBahcivan, E.
dc.contributor.authorFaki, H. Eser
dc.contributor.authorYazar, E.
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this research was to determine the effects of Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillation (NOD) on the colon aberrant cryptal foci (ACF) score, serum cytokines [Tumour necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-6, IL-10], prostaglandin E2, and oxidative status parameters (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase) in an experimentally induced colon cancer model in rats. Male rats (38 in total) were divided into 4 groups: Control group (n = 8), Colon Cancer group (CC, n = 10), CC+TCAE group (n = 10), and CC i NOD group (n = 10). Except for the Control group, the rest of rats received azoxymethane (15 mg/kg, SC) once a week for two weeks to induce colon cancer. TCAE was administered once a week at 0.2 mL/kg (SC) and NOD was administered in water to CC+TCAE and CC+NOD groups for 18 weeks. After blood samples were collected, the rats were euthanized, colons were removed, washed with saline, then fixed with 10% formaldehyde, and stained with 0.2% methylene blue. ACFs were scored by light microscopy. Serum levels of cytokines, prostaglandin E2, and oxidative status parameters were determined with ELISA. ACF score of the CC group was higher than CC+TCAE and CC+NOD groups. The prostaglandin E2 level of the Control group was lower than the CC i TCAE group, while IL-2 and IL-10 levels of the Control group were lower than all other groups. In conclusion, it can be stated that TCAE and NOD applications may be beneficial in the treatment of colon cancer.
dc.description.sponsorshipSUBAPK [17401073]
dc.description.sponsorshipThis study was financed by SUBAPK (17401073). Study abstract was present as oral presentation in the International Conference on Veterinary, Agriculture and Life Sciences (ICVALS), October 26-29, 2018, Antalya, Turkey
dc.identifier.endpage21
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue1-3
dc.identifier.scopus2-s2.0-85061377099
dc.identifier.scopusqualityN/A
dc.identifier.startpage15
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8138
dc.identifier.volume170
dc.identifier.wosWOS:000458184200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEcole Nationale Veterinaire Toulouse
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectTarantula cubensis alcoholic extract
dc.subjectNerium oleander distillate
dc.subjectcolon cancer
dc.titleEffects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer
dc.typeArticle

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