Potential Recruiting and Hepatoprotective Effects of Ellagic Acid in D-Galactosamine-Induced Liver Damage in Rats

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dc.authoridKutlu, Mehtap/0000-0002-8816-1487
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAli, Jama Hussein
dc.contributor.authorKutlu, H. Mehtap
dc.contributor.authorVejselova, Djanan
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:30:30Z
dc.date.available2024-12-24T19:30:30Z
dc.date.issued2017
dc.departmentSiirt Üniversitesi
dc.description.abstractThe present study aims to investigate the therapeutic and protective effects of ellagic acid (EA) on the toxicity of the liver induced by D-Galactosamine (D-GaIN) in rats. With this in mind, the rats were categorized into five groups. The study groups were given saline, 0.2 % dimethyl sulfoxide, D-GaIN, EA plus D-GaIN and D-GaIN plus EA, respectively. In the group given D-GaIN, the following transmission electron microscopic and light microscopic results were found: degenerative changes in the liver tissue, significant decreased in the number of activated Bcl-2, while increased in the number of Bax and caspase-3-positive hepatocytes, a significantly increase in levels of the activities of biochemistry markers (serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP)). In contrast, in the groups given D-GaIN and EA, a decrease in the damage of the liver tissue, a significant decrease activated Bax and caspase-3-positive hepatocytes, while increase in the number of Bcl-2 positive hepatocytes, a decrease in the biochemistry markers levels were found. Group 4, given EA before D-GaIN, showed better results when compared to Group 5, given EA after D-GaIN, in terms of histopathological and biochemical values. In conclusion, EA might play an important role in repairing D-GaIN-induced liver damage both as a protective and a therapeutic agent.
dc.description.sponsorshipAnadolu University Scientific Research Project Unit [1501E028, 2014-22]
dc.description.sponsorshipThis work was supported by Anadolu University Scientific Research Project Unit (Project No: 1501E028, Ethical Committee No: 2014-22).
dc.identifier.doi10.17582/journal.pjz/2017.49.4.1251.1259
dc.identifier.endpage1259
dc.identifier.issn0030-9923
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85027453129
dc.identifier.scopusqualityQ4
dc.identifier.startpage1251
dc.identifier.urihttps://doi.org/10.17582/journal.pjz/2017.49.4.1251.1259
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7530
dc.identifier.volume49
dc.identifier.wosWOS:000428835100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherZoological Soc Pakistan
dc.relation.ispartofPakistan Journal of Zoology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectD-GaIN
dc.subjectEllagic acid
dc.subjectHepatotoxicity
dc.subjectTEM
dc.subjectRats
dc.titlePotential Recruiting and Hepatoprotective Effects of Ellagic Acid in D-Galactosamine-Induced Liver Damage in Rats
dc.typeArticle

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