Chipset Nanosensor Based on N-Doped Carbon Nanobuds for Selective Screening of Epinephrine in Human Samples

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dc.authoridEl-Safty, Sherif/0000-0001-5992-9744
dc.authoridelmarakbi, ahmed/0000-0002-7479-3870
dc.authoridShenashen, Mohamed/0000-0003-1592-5877
dc.authoridEmran, Mohammed Y./0000-0002-0605-7118
dc.contributor.authorEmran, Mohammed Y.
dc.contributor.authorEl-Safty, Sherif A.
dc.contributor.authorElmarakbi, Ahmed
dc.contributor.authorReda, Abduallah
dc.contributor.authorEl Sabagh, Ayman
dc.contributor.authorShenashen, Mohamed A.
dc.date.accessioned2024-12-24T19:24:07Z
dc.date.available2024-12-24T19:24:07Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractChipset nanosensor design and fabrication are important for healthcare research and development. Herein, a functionalized chipset nanosensor is designed to monitor neurotransmitters (i.e., epinephrine (EP)) in human fluids. An interdigitated electrode array (IDA) is functionalized by N-doped carbon nanobud (N-CNB) and N-doped carbon nanostructure (N-CNS). The surface morphology of N-CNB shows the formation of nanotubular-like branches on sheets and micrometer-size tubes. The N-CNS design consists of the formation of aggregated sheets and particles in nanometer size. The irregular shape formation provides surface heterogeneity and numerous free spaces between the stacked nanostructures. N-atoms ascertain highly active N-CNS with multifunctional active centers, electron-rich charged surface, and short distance pathway. The N-CNB/IDA exhibits the best performance for EP signaling with high sensitivity and selectivity. The N-CNB/IDA sensing performance for EP detection indicates the successful design of a highly selective and sensitive assay with low detection limit of 0.011 x 10(-6) m and a broad linear range of 0.5 x 10(-6) to 3 x 10(-6) m. The N-CNB/IDA exhibits a high degree of accuracy and reproducibility with RSD of 2.7% and 3.9%, respectively. Therefore, the chipset nanosensor of N-CNB/IDA can be used for on-site monitoring of EP in human serum samples and further used in daily monitoring of neuronal disorders.
dc.description.sponsorshipJapan Society for the Promotion of Science (JSPS) [P19067]
dc.description.sponsorshipThis work was supported by the Japan Society for the Promotion of Science (JSPS) (Grant No. P19067).
dc.identifier.doi10.1002/admi.202101473
dc.identifier.issn2196-7350
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85119678372
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/admi.202101473
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5836
dc.identifier.volume9
dc.identifier.wosWOS:000721431100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAdvanced Materials Interfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectadvanced nanocarbon materials
dc.subjectelectrochemical sensors
dc.subjectbiosensors
dc.subjectfunctionalized electrodes
dc.subjectnitrogen-doped carbon-based materials
dc.subjectportable nanosensors
dc.subjectsensitive and selective epinephrine assay
dc.titleChipset Nanosensor Based on N-Doped Carbon Nanobuds for Selective Screening of Epinephrine in Human Samples
dc.typeArticle

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