Phenotypic and Genotypic Characterization of Macrolide-Lincosamide-Streptogramin Resistance in Staphylococcus aureus Isolates from Bovine and Human

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dc.authoridEKIN, Ismail Hakki/0000-0001-5029-8130
dc.authoridGULAYDIN, Ozgul/0000-0001-8376-2008
dc.contributor.authorGulaydin, Ozgul
dc.contributor.authorGurturk, Kemal
dc.contributor.authorEkin, Ismail Hakki
dc.contributor.authorIlhan, Ziya
dc.contributor.authorArabaci, Cigdem
dc.date.accessioned2024-12-24T19:30:47Z
dc.date.available2024-12-24T19:30:47Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, penicillin, oxacillin, and macrolide-lincosamide-streptogramin (MLS) resistance in S. aureus strains that were isolated from bovine mastitis cases, and human patients were investigated. Inducible clindamycin resistance (iML) was not found in 30 bovine isolates, while it was detected in 3 (10%) of 30 human isolates. MIC90 values of penicillin, oxacillin and macrolide-lincosamides (ML) were 2, 0.19, > 256 mu g/ml in bovine isolates and were 3, 3 and 0.19-1.5 mu g/ml in human isolates, respectively. Streptogramin resistance was not found in both bovine and human isolates. Although the mecA gene was detected in all of the oxacillin resistant isolates, blaZ gene could not be detected in penicillin resistant isolates. The erm(B) gene was detected in 5 (38.6%) of 13 ML-resistant bovine isolates, and the mph(C) gene was detected in 2 (66.66%) of 3 human isolates. As a result, resistance to penicillin and oxacillin was found to be higher in human S. aureus isolates, while ML resistance was found to be higher in bovine isolates in this investigation. It was concluded that the presence of genes in extra-chromosomal elements associated to penicillin and macrolide resistance should be investigated. The data obtained from this study will contribute to the studies on antimicrobial susceptibility in the field of human and veterinary medicine.
dc.description.sponsorshipResearch Fund of Van Yuezuencue Yil University [TSA-2021-9310]
dc.description.sponsorshipThis study was supported by Research Fund of Van Yuezuencue Yil University with the project number of TSA-2021-9310.
dc.identifier.doi10.2478/acve-2023-0008
dc.identifier.endpage118
dc.identifier.issn0567-8315
dc.identifier.issn1820-7448
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85150277683
dc.identifier.scopusqualityQ3
dc.identifier.startpage102
dc.identifier.urihttps://doi.org/10.2478/acve-2023-0008
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7683
dc.identifier.volume73
dc.identifier.wosWOS:000952407400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofActa Veterinaria-Beograd
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectbovine
dc.subjecthuman
dc.subjectmastitis
dc.subjectMLS resistance
dc.subjectStaphylococcus aureus
dc.titlePhenotypic and Genotypic Characterization of Macrolide-Lincosamide-Streptogramin Resistance in Staphylococcus aureus Isolates from Bovine and Human
dc.typeArticle

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