Synthesis of ionic liquid-based Ru(II)-phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA-binding, and DNA cleavage activities

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dc.authoridZazybin, Alexey/0000-0002-6244-9327
dc.authoridRafikova, Khadichakhan/0000-0001-8028-2244
dc.authoridAydemir, Murat/0000-0002-4238-5012
dc.authoridKAYAN, Cezmi/0000-0001-5700-8546
dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.contributor.authorMeric, Nermin
dc.contributor.authorKayan, Cezmi
dc.contributor.authorRafikova, Khadichakhan
dc.contributor.authorZazybin, Alexey
dc.contributor.authorOkumus, Veysi
dc.contributor.authorAydemir, Murat
dc.contributor.authorDurap, Feyyaz
dc.date.accessioned2024-12-24T19:24:52Z
dc.date.available2024-12-24T19:24:52Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractTwo Ru(II) complexes were synthesized by reaction of phosphinite-functionalized imidazolium salts [(Ph2PO)C7H11N2Cl]Cl (1) and [(Cy2PO)C7H11N2Cl]Cl (2) with 1/2 equivalent of [Ru(eta(6)-p-cymene)(mu-Cl)Cl](2) in anhydrous CH2Cl2 and under argon atmosphere. The complexes were then isolated as analytically pure substances and characterized using multinuclear NMR and infrared spectroscopies and elemental analysis. The Ru(II) compounds were used to study their biological assay. For this purpose, radical scavenging, reducing power, antibacterial activity, DNA binding, and DNA cleavage activity were fully studied. The maximum 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) scavenging (78.9%) and reducing power were obtained from compound 4 at the concentration of 200 mu g/ml. The compounds were also tested against three Gram-positive and three Gram-negative bacteria, and they were found to be more effective against Gram-positive bacteria. In addition, both compounds showed excellent DNA binding and DNA cleavage activity.
dc.description.sponsorshipDicle University Research Fund [FEN.17.023, FEN.17.019]; Ministry of Education and Science of the Republic of Kazakhstan [IRN: AP05132833, BR05236800, BR05236302]
dc.description.sponsorshipPartial support from Dicle University Research Fund (Project numbers: FEN.17.023 and FEN.17.019) is gratefully acknowledged. The authors would also like to thank the Ministry of Education and Science of the Republic of Kazakhstan for the financial support (IRN: AP05132833, BR05236800 and BR05236302).
dc.identifier.doi10.1007/s11696-018-00670-0
dc.identifier.endpage1208
dc.identifier.issn2585-7290
dc.identifier.issn1336-9075
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85064255922
dc.identifier.scopusqualityQ2
dc.identifier.startpage1199
dc.identifier.urihttps://doi.org/10.1007/s11696-018-00670-0
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6173
dc.identifier.volume73
dc.identifier.wosWOS:000463985400016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer International Publishing Ag
dc.relation.ispartofChemical Papers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectIonic liquid
dc.subjectPhosphinite
dc.subjectRuthenium
dc.subjectAntibacterial
dc.subjectDNA binding
dc.subjectDNA cleavage
dc.titleSynthesis of ionic liquid-based Ru(II)-phosphinite complexes and evaluation of their antioxidant, antibacterial, DNA-binding, and DNA cleavage activities
dc.typeArticle

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