The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice

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dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2024-12-24T19:18:57Z
dc.date.available2024-12-24T19:18:57Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractSilymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitoticactivities against a broad range of cancers, such as prostate, colon, ovarian, skinand lung cancer. This study targets to determine the protective effects of Sm on lungdamage in the mice exposed to D-galactosamine (D-GaIN)/tumour necrosis factor alpha(TNF-?). For this purpose, three groups of Balb/c mice were used. The study groupswere given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-? plus Sm, respectively.Our biochemistry, apoptotic markers and light microscopic findings offer that Sm cannoticeably diminish D-GaIN/TNF?-induced pulmonary toxicity. In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a. This caringeffect might be thanks to the capability of Sm to keep oxidant–antioxidant stability.
dc.identifier.endpage52
dc.identifier.issn2147-1630
dc.identifier.issn2146-586X
dc.identifier.issue1
dc.identifier.startpage42
dc.identifier.trdizinid292006
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/292006
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5434
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAdıyaman Üniversitesi Fen Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectTıbbi Araştırmalar Deneysel,Solunum Sistemi,Onkoloji,Biyokimya ve Moleküler Biyoloji
dc.titleThe Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice
dc.typeArticle

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