The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice
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Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Silymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitoticactivities against a broad range of cancers, such as prostate, colon, ovarian, skinand lung cancer. This study targets to determine the protective effects of Sm on lungdamage in the mice exposed to D-galactosamine (D-GaIN)/tumour necrosis factor alpha(TNF-?). For this purpose, three groups of Balb/c mice were used. The study groupswere given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-? plus Sm, respectively.Our biochemistry, apoptotic markers and light microscopic findings offer that Sm cannoticeably diminish D-GaIN/TNF?-induced pulmonary toxicity. In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a. This caringeffect might be thanks to the capability of Sm to keep oxidant–antioxidant stability.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel,Solunum Sistemi,Onkoloji,Biyokimya ve Moleküler Biyoloji
Kaynak
Adıyaman Üniversitesi Fen Bilimleri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
1
