Preparation and spectral studies of boronate ester modified magnetite iron nanoparticles (Fe3O4@APTES-B) as a new type of biological agents

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dc.contributor.authorKilic, Ahmet
dc.contributor.authorKaratas, M. Emin
dc.contributor.authorBeyazsakal, Levent
dc.contributor.authorOkumus, Veysi
dc.date.accessioned2024-12-24T19:27:29Z
dc.date.available2024-12-24T19:27:29Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractWe have designed two novel magnetite targeting biological agents (Fe3O4@APTES-B-(1,B-2)) with a core of Fe3O4 and a shell made of boronate esters (APTES-B) to improve the biological effectiveness of magnetite Fe3O4 nanoparticles (MNPs). Initially, two boronate esters (B-1) and (B-2) have been prepared by 3,4dihydroxybenzaldehyde and phenylboronic acid and/or butylboronic acid using a Dean-Stark apparatus to remove the water formed during the esterification reactions. Then, the APTES-B-1,(2) compounds have been synthesized via boronate esters and APTES in the presence of 1-2 drops of formic acid as catalyst. Finally, magnetite Fe3O4 NPs were added to APTES-B-1,B-2 compounds to afford boronate ester modified magnetite iron nanoparticles (Fe3O4@APTES-B-1,B-2) at ambient temperature, respectively. The boronate esters (B-1) and (B-2), APTES-B-1,B-2 compounds, and boronate ester modified magnetite iron nanoparticles (Fe3O4@APTES-B-1,B-2) were characterized using a combination of NMR (H-1, C-13, and B-11), FT-IR, UV-Vis, LC-MS/MS, elemental analysis (CHN), XRD, SEM-EDX, EDX mapping, BET, and TG-DTA). Then, the antioxidant, antimicrobial and DNA binding activities of newly synthesized target compounds were tested. These results suggest that all compounds are also one of the propitious drug candidates and are worthy of further investigation. (C) 2022 Elsevier B.V. All rights reserved.
dc.description.sponsorshipResearch Fund of Harran University (HUBAP) [21145]
dc.description.sponsorshipAcknowledgements This work was supported by the Research Fund of Harran University (HUBAP Project No: 21145)
dc.identifier.doi10.1016/j.molliq.2022.119602
dc.identifier.issn0167-7322
dc.identifier.issn1873-3166
dc.identifier.scopus2-s2.0-85132326935
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molliq.2022.119602
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6663
dc.identifier.volume361
dc.identifier.wosWOS:000832893300013
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Liquids
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectBoronate ester
dc.subjectAPTES-B-1
dc.subject2
dc.subjectFe3O4@APTES-B MNPs
dc.subjectSpectroscopy
dc.subjectAntimicrobial studies
dc.titlePreparation and spectral studies of boronate ester modified magnetite iron nanoparticles (Fe3O4@APTES-B) as a new type of biological agents
dc.typeArticle

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