ICP-OES AND LC-ESI-MS/MS ANALYSES, ENZYME INHIBITION AND DNA PROTECTION POTENTIAL OF PELARGONIUM QUERCETORUM AGNEW

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dc.contributor.authorAkkemik, Ebru
dc.contributor.authorFidan, Mehmet
dc.contributor.authorBalaban, Merve
dc.contributor.authorInal, Behcet
dc.date.accessioned2024-12-24T19:30:46Z
dc.date.available2024-12-24T19:30:46Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractPelargonium quercetorum Agnew extract affects activities of acetylcholinesterase (AChE) and carbonic anhydrase I-II enzymes (hCA I-II) was investigated under in vitro conditions. IC50 values of P. quercetorum Agnew on hCA I-II and AChE activity were determined as 0.144 +/- 0.0720, 0.209 +/- 0.0593, and 0.062 +/- 0.0097 mg/mL, respectively. Rutin and shikimic acid was found to be the main phenolic component in P. quercetorum Agnew flower extract from the results of LC-ESI-MS/MS analysis. Rutin was found to be the main phenolic component in P. quercetorum Agnew leaf extract from the results of LC-ESIMS/MS analysis. ICP-OES analysis showed that the leaves of P. quercetorum Agnew were rich in potassium. The DNA protective effect on plasmid DNA was demonstrated by using extracts obtained from leaf and flower tissues. Consequently, based on the findings of the current study, it could be anticipated that clinical trials related to P. quercetorum Agnew could be completed and the plant could be used pharmacologically.
dc.identifier.doi10.24193/subbchem.2022.4.13
dc.identifier.endpage213
dc.identifier.issn1224-7154
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85146392177
dc.identifier.scopusqualityQ4
dc.identifier.startpage197
dc.identifier.urihttps://doi.org/10.24193/subbchem.2022.4.13
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7669
dc.identifier.volume67
dc.identifier.wosWOS:000934800100014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Babes-Bolyai
dc.relation.ispartofStudia Universitatis Babes-Bolyai Chemia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectAcetylcholinesterase
dc.subjectCarbonic anhydrase
dc.subjectDNA protection
dc.subjectICPOES
dc.subjectP. quercetorum Agnew
dc.titleICP-OES AND LC-ESI-MS/MS ANALYSES, ENZYME INHIBITION AND DNA PROTECTION POTENTIAL OF PELARGONIUM QUERCETORUM AGNEW
dc.typeArticle

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