Antioxidant properties of Ferulago angulata and its hepatoprotective effect against Nnitrosodimethylamine- induced oxidative stress in rats

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dc.date.accessioned2019-11-29T07:24:16Z
dc.date.available2019-11-29T07:24:16Z
dc.date.issued2017en_US
dc.departmentVeteriner Fakültesien_US
dc.description.abstractABSTRACT Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats. Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB methanol extract (150 and 300 mg/kg) was administered orally for 21 days. Results: a-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70 ± 0.13, 0.29 ± 0.03 lg/g, 139.32 ± 7.06 lg/100 g, 171.61 ± 6.05mM ascorbic acid/g, 90.47 ± 4.11mg GA/g and 37.39 ± 2.85mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC50 67.34 ± 4.14 and 64.87 ± 4.68 lg/mL, respectively. Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.en_US
dc.identifier.issue1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/2109
dc.identifier.volume55en_US
dc.institutionauthorkızıltaş, hatice
dc.institutionauthorekin, suat
dc.institutionauthorbayramoglu, mahire
dc.institutionauthorakbaş, esvet
dc.institutionauthoroto, gökhan
dc.institutionauthoryıldırım, serkan
dc.institutionauthorözgökçe, fevzi
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectFerulago angulata; Antioxidant capacity; SOD; GSH-Px; CATen_US
dc.titleAntioxidant properties of Ferulago angulata and its hepatoprotective effect against Nnitrosodimethylamine- induced oxidative stress in ratsen_US
dc.typeArticleen_US

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