Antioxidant properties of Ferulago angulata and its hepatoprotective effect against Nnitrosodimethylamine- induced oxidative stress in rats
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Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
ABSTRACT
Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been
used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant
compounds.
Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins,
and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA)
induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar
albino rats.
Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals
were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB
methanol extract (150 and 300 mg/kg) was administered orally for 21 days.
Results: a-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of
FASB were 0.70 ± 0.13, 0.29 ± 0.03 lg/g, 139.32 ± 7.06 lg/100 g, 171.61 ± 6.05mM ascorbic acid/g,
90.47 ± 4.11mg GA/g and 37.39 ± 2.85mg QE/g. DPPH and hydroxyl radical scavenging activity was
obtained IC50 67.34 ± 4.14 and 64.87 ± 4.68 lg/mL, respectively.
Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of
vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant
changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that
the plant could be used as a hepatoprotective.
Açıklama
Anahtar Kelimeler
Ferulago angulata; Antioxidant capacity; SOD; GSH-Px; CAT
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
55
Sayı
1
