Theophylline attenuates bleomycin-induced oxidative stress in rats: The role of IL-6, NF-KB, and antioxidant enzymes

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dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorEkin, Suat
dc.contributor.authorYildirim, Serkan
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorGok, Hasya Nazli
dc.contributor.authorArihan, Okan
dc.contributor.authorOto, Gokhan
dc.contributor.authorAkkoyun, Turan
dc.date.accessioned2024-12-24T19:30:20Z
dc.date.available2024-12-24T19:30:20Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractThe purpose of this study was to evaluate the antifibrotic and antioxidant roles of theophylline (Theo), a bioactive compound, in bleomycin (BLM)-induced pulmonary fibrosis in Wistar albino rats. Assigned into 4 groups were 32 Wistar albino rats, comprising the control group (administered 0.9% isotonic saline), BLM group (treated with BLM at a dose of 2.5 mg/kg), BLM+Theo group (treated with Theo at a dose of 75 mg/kg + BLM at a dose of 2.5 mg/kg), and Theo group (treated with Theo at a dose of 75 mg/kg). In the BLM group, a significant decrease was observed in the catalase and glutathione peroxidase enzyme activities, and reduced glutathione (GSH) (p < 0.05, p < 0.05, p < 0.001, respectively), while the malondialdehyde (MDA) levels (p < 0.001) were significantly elevated when compared to the control group. However, the MDA levels in the BLM+Theo group were also significantly higher than in the control group (p < 0.01). Similarly, the GSH levels were significantly higher in the BLM+Theo group than in the BLM group (p < 0.05). The results indicated that Theo reduced the BLM-induced activation of nuclear factor-kappaB (NF-kappa B) and decreased interleukin-6 (IL-6) levels, together with significant amelioration of the immunohistochemical and histopathological architecture in the lung tissues. It was concluded that the administration of Theo had a positive effect on the GSH level, and activation of NF-kappa B and IL-6 expression, which were significant proinflammatory markers in the BLM-treated rats.
dc.identifier.doi10.1590/s2175-97902022e20827
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85144165270
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e20827
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7493
dc.identifier.volume58
dc.identifier.wosWOS:000904499400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectTheophylline
dc.subjectBleomycin
dc.subjectIL-6
dc.subjectNF-?B
dc.subjectAntioxidant enzymes
dc.titleTheophylline attenuates bleomycin-induced oxidative stress in rats: The role of IL-6, NF-KB, and antioxidant enzymes
dc.typeArticle

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