EFFECTS OF CEFAN MELON (CUCUMIS MELO L.) SEED EXTRACTS ON HUMAN ERYTHROCYTE CARBONIC ANHYDRASE I-II ENZYMES

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dc.contributor.authorAkkemik, E.
dc.contributor.authorAybek, A.
dc.contributor.authorFelek, I
dc.date.accessioned2024-12-24T19:30:15Z
dc.date.available2024-12-24T19:30:15Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractCarbonic anhydrases (CAs, E.C.4.2.1.1) are an important metalloenzyme family that catalyzes reversible CO2 hydration and HCO3- dehydration in organisms. CA inhibitors can be used in the treatment of many diseases such as glaucoma, epilepsy, obesity, and cancer. This study aimed to determine the effects of oil and methanol extracts of Cefan melon (Cucumis melo L.) seed (CMS) on CA enzyme activity. While both extracts activated hCA-I isoenzyme, they inhibited hCA-II. In order to determine the active substance causing inhibition or activation in CMS, essential oil content, phenolic substance profile and macro-micronutrient elements were investigated. Dominant fatty acids were identified as linoleic and oleic acid, while the dominant phenolic compound was gallic acid. Besides, it was found that CMS contained high concentrations of Ca, K and Na, and was rich in Se. Results demonstrated that essential oil and phenolic compounds in Cefan melon have potential applications as alternative natural products for pharmaceutical industries. In addition, Cefan melon seed has a wide range of applications for food and cosmetic industries based on the research into the fatty acid, phenolic content, and nutrient elements.
dc.identifier.doi10.15666/aeer/1706_1469914713
dc.identifier.endpage14713
dc.identifier.issn1589-1623
dc.identifier.issn1785-0037
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85077395359
dc.identifier.scopusqualityQ3
dc.identifier.startpage14699
dc.identifier.urihttps://doi.org/10.15666/aeer/1706_1469914713
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7446
dc.identifier.volume17
dc.identifier.wosWOS:000505251300140
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCorvinus Univ Budapest
dc.relation.ispartofApplied Ecology and Environmental Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectinhibition
dc.subjectactivation
dc.subjectfatty acid
dc.subjectphenolic compound
dc.subjectICP MS
dc.titleEFFECTS OF CEFAN MELON (CUCUMIS MELO L.) SEED EXTRACTS ON HUMAN ERYTHROCYTE CARBONIC ANHYDRASE I-II ENZYMES
dc.typeArticle

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