DNA cleavage properties and synthesis of metallophthalocyanines with 5-methyl-[1,2,4] triazolo [1, 5-a] pyrimidin-7-oxy substituents

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dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.contributor.authorAgirtas, M. Salih
dc.contributor.authorOndes, M. Yusuf
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorOkumus, Veysi
dc.date.accessioned2024-12-24T19:28:26Z
dc.date.available2024-12-24T19:28:26Z
dc.date.issued2017
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of the present study is to perform synthesis of novel metallophthalocyanines (pcs) with high solubility. The synthesis and characterization of 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted zinc, magnesium, and cobalt pcs are reported. These compounds have been characterized using electronic absorption, nuclear magnetic resonance spectroscopy, infrared, elemental analysis and mass spectra. The aggregation investigations carried out in different concentrations indicate that 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted pc complexes do not have any aggregation behavior for the concentration range of 1 x 10(-5) -1 x 10(-6) M in THF. DPPH radical scavenging activity, metal chelating activity, and reducing power of the compounds were evaluated. The DNA gel electrophoresis studies revealed that new phthalonitrile and its metallophthalocyanine compounds cleavaged plasmid DNA (pBR322). Additionally, the ground-state geometries of the complexes were optimized using density functional theory methods at B3LYP/6-31G (d, p) level in order to obtain information about the 3D geometries and electronic structure.
dc.description.sponsorshipYuzuncu Yil University
dc.description.sponsorshipThis study was supported by the Research Fund of Yuzuncu Yil University.
dc.identifier.doi10.1080/24701556.2017.1284086
dc.identifier.endpage1102
dc.identifier.issn2470-1556
dc.identifier.issn2470-1564
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85026846451
dc.identifier.scopusqualityQ2
dc.identifier.startpage1097
dc.identifier.urihttps://doi.org/10.1080/24701556.2017.1284086
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7055
dc.identifier.volume47
dc.identifier.wosWOS:000396522500023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofInorganic and Nano-Metal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectPhthalocyanine
dc.subjectsynthesis
dc.subjectelectronic structure
dc.subjectaggregation
dc.subjectDNA cleavage
dc.titleDNA cleavage properties and synthesis of metallophthalocyanines with 5-methyl-[1,2,4] triazolo [1, 5-a] pyrimidin-7-oxy substituents
dc.typeArticle

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