Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

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dc.authoridTEGIN, IBRAHIM/0000-0002-5661-7195
dc.contributor.authorUstun, Cemal
dc.contributor.authorTegin, Ibrahim
dc.contributor.authorGeyik, Mehmet Faruk
dc.date.accessioned2024-12-24T19:32:55Z
dc.date.available2024-12-24T19:32:55Z
dc.date.issued2012
dc.departmentSiirt Üniversitesi
dc.description.abstractObjective: To determine the alterations of serum copper (Cu) and zinc (Zn) levels and Cu/Zn ratio in patients with brucellosis. Material and Methods: A total of 170 individuals were included in the study. Of these, 45 (26.5%) currently had acute or sub-acute brucellosis, 35 (20.6%) were previously diagnosed with acute or sub-acute brucellosis and successfully treated, and 90 (52.9%) were healthy volunteers. After fasting overnight for 10 hours, 5 ml of venous blood was taken from all subjects. Serum Cu and Zn levels were measured using a Unicam 929 Atomic Absorption Spectrophotometer. SPSS 16.0 was used for data analysis. Results: Mean serum Cu levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with acute or sub-acute brucellosis and 90 healthy volunteers were 88.6 +/- 26, 58.7 +/- 13 and 56.7 +/- 16 mu g/dL, respectively. Mean serum Zn levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with and treated successfully for acute or sub-acute brucellosis and 90 healthy volunteers were 38.3 +/- 12, 58.5 +/- 14, and 55.8 +/- 13 mu g/dL, respectively. Serum Cu levels (p<0.001) and Cu/Zn ratios (p<0.001) were statistically significantly higher while serum Zn levels (p<0.001) were lower in patients with acute or sub-acute brucellosis when compared to the individuals who previously diagnosed with acute or sub-acute brucellosis and the healthy volunteers. Conclusion: This study revealed significant alterations of serum Cu and Zn levels, and Cu/Zn ratios in patients with acute or sub-acute brucellosis. Serum Cu, Zn, and Cu/Zn ratios may be available biomarkers in the course of acute or sub-acute brucellosis.
dc.identifier.doi10.5336/medsci.2011-25720
dc.identifier.endpage983
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84860116389
dc.identifier.scopusqualityQ4
dc.identifier.startpage979
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-25720
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7880
dc.identifier.volume32
dc.identifier.wosWOS:000309698500011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherOrtadogu Ad Pres & Publ Co
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectBrucellosis
dc.subjectcopper
dc.subjectzinc
dc.subjecttrace elements
dc.subjectserum
dc.subjectbiological markers
dc.titleAlterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis
dc.title.alternativeBrusellozlu hastalarda Serum Bakır ve çinko düzeylerindeki ve bakı/çinko oranlarındaki de?işiklikler
dc.typeArticle

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