Phenolic Contents, Enzyme Inhibitory Activities, and Protective Effect of Aqueous Extract of Rosa Pisiformis Fruits

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dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorEkin, Suat
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorGok, Hasya Nazli
dc.contributor.authorOto, Gokhan
dc.contributor.authorAkkoyun, Turan
dc.contributor.authorOzgokce, Fevzi
dc.date.accessioned2024-12-24T19:24:44Z
dc.date.available2024-12-24T19:24:44Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThe present study was designed to assess the phytochemical contents as well as the in vitro biological activities fruit of Rosa pisiformis and possible in vivo cardioprotective and hepatoprotective properties of the aqueous extract of R. pisiformis fruit on trace elements (cadmium, selenium, nickel, zinc, iron, copper, cobalt, chromium, manganese, lead), minerals (sodium, calcium, potassium, magnesium), glutathione and malondialdehyde in heart and liver tissue samples, serum vitamin (retinol, cholecalciferol, phylloquinone, alpha-tocopherol), total sialic acid, and lipid-bound sialic acid in a rat model of isoproterenol-induced oxidative damage. In the study, 40 Wistar albino rats were divided into four groups of ten each: control, isoproterenol 100 mg/kg bodyweight; isoproterenol 100 mg/kg bodyweight; then R. pisiformis 300 mg/kg bodyweight, and R. pisiformis 300 mg/kg bodyweight. Rats were given isoproterenol twice at an interval of 24 h for two days (on days 28 and 29) subcutaneously. The experimental period was maintained at 30 days. According to analysis results, caffeic acid and p-coumaric acid were found to be the high contents of the fruit extracts at 6.01 +/- 0.0006 and 3.93 +/- 0.007 mg/100 g dry weight. It showed that R. pisiformis (300 mg/kg bodyweight) aqueous extract had a potent action on oxidative damage. The R. pisiformis (300 mg/kg bodyweight) treatment significantly alleviated toward normalcy on the zinc, manganese, cobalt, magnesium, and sodium values in the heart, and zinc and magnesium values in liver tissue samples. These positive effects may be related to the action of p-coumaric acid and caffeic acid present in the R. pisiformis 300 mg/kg and it has hypolipidemic and antioxidant properties that could protect from myocardial damage.
dc.identifier.doi10.1007/s11094-024-03081-6
dc.identifier.endpage1806
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85187939575
dc.identifier.scopusqualityQ4
dc.identifier.startpage1799
dc.identifier.urihttps://doi.org/10.1007/s11094-024-03081-6
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6120
dc.identifier.volume57
dc.identifier.wosWOS:001185563600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectRosa pisiformis
dc.subjectIsoproterenol
dc.subjecttrace element
dc.subjectmineral
dc.subjectvitamin
dc.subjecttotal sialic acid
dc.titlePhenolic Contents, Enzyme Inhibitory Activities, and Protective Effect of Aqueous Extract of Rosa Pisiformis Fruits
dc.typeArticle

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