Heavy metal ion inhibition studies of human, sheep and fish ?-carbonic anhydrases

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dc.contributor.authorDemirdag, Ramazan
dc.contributor.authorYerlikaya, Emrah
dc.contributor.authorSenturk, Murat
dc.contributor.authorKufrevioglu, Omer Irfan
dc.contributor.authorSupuran, Cladiu T.
dc.date.accessioned2019-11-18T10:35:25Z
dc.date.available2019-11-18T10:35:25Z
dc.date.issued2013
dc.departmentBelirleneceken_US
dc.description.abstractCarbonic anhydrases (CAs, EC 4.2.1.1) were purified from sheep kidney (sCA IV), from the liver of the teleost fish Dicentrarchus labrax (dCA) and from human erythrocytes (hCA I and hCA II). The purification procedure consisted of a single step affinity chromatography on Sepharose 4B-tyrosine-sulfanilamide. The kinetic parameters of these enzymes were determined for their esterase activity with 4-nitrophenyl acetate as substrate. The following metal ions, Pb2+, Co2+, Hg2+, Cd2+, Zn2+, Se2+, Cu2+, Al3+ and Mn3+ showed inhibitory effects on these enzymes. The tested metal ions inhibited these CAs competitively in the low milimolar/submillimolar range. The susceptibility to various cations inhibitors differs significantly between these vertebrate ?-CAs and is probably due to their binding to His64 or the histidine cluster.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12604/1615
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz#KayıtKontrol#
dc.subjectCarbonic anhydrase, metal ion, erythrocyte, sheep kidney, teleost fishen_US
dc.titleHeavy metal ion inhibition studies of human, sheep and fish ?-carbonic anhydrasesen_US
dc.typeArticleen_US

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