In vitro inhibition of purified human carbonic anhydrase I and II by novel fluorene derivatives

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dc.contributor.authorDemirhan, Hulya
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKaya, Mustafa Oguzhan
dc.contributor.authorKaya, Yesim
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2024-12-24T19:10:08Z
dc.date.available2024-12-24T19:10:08Z
dc.date.issued2014
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 ?M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 ?M) for inhibition of hCA II.
dc.identifier.doi10.20450/mjcce.2014.440
dc.identifier.endpage207
dc.identifier.issn1857-5552
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84929335728
dc.identifier.scopusqualityQ3
dc.identifier.startpage199
dc.identifier.urihttps://doi.org10.20450/mjcce.2014.440
dc.identifier.urihttps://hdl.handle.net/20.500.12604/3948
dc.identifier.volume33
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMacedonian Journal of Chemistry and Chemical Engineering
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subject9-benzylidene-9H-fluorene
dc.subjectCarbonic anhydrase
dc.subjectInhibition
dc.subjectThiourea
dc.subjectUrea
dc.titleIn vitro inhibition of purified human carbonic anhydrase I and II by novel fluorene derivatives
dc.typeArticle

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