In vitro inhibition of purified human carbonic anhydrase I and II by novel fluorene derivatives
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Tarih
2014
Yazarlar
Demirhan, Hulya
Arslan, Mustafa
Kaya, Mustafa Oguzhan
Kaya, Yesim
Gencer, Nahit
Arslan, Oktay
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Macedonian Journal of Chemistry and Chemical Engineering
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 ?M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 ?M) for inhibition of hCA II.
Açıklama
Anahtar Kelimeler
9-benzylidene-9H-fluorene, Carbonic anhydrase, Inhibition, Thiourea, Urea
Kaynak
Macedonian Journal of Chemistry and Chemical Engineering
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
33
Sayı
2
