In vitro inhibition of purified human carbonic anhydrase I and II by novel fluorene derivatives
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Macedonian Journal of Chemistry and Chemical Engineering
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 ?M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 ?M) for inhibition of hCA II.
Açıklama
Anahtar Kelimeler
9-benzylidene-9H-fluorene, Carbonic anhydrase, Inhibition, Thiourea, Urea
Kaynak
Macedonian Journal of Chemistry and Chemical Engineering
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
33
Sayı
2
