The Effect of Rosa Pisiformis (Christ) D.Sosn on Some Metabolic Enzyme Activities in STZ Applied Diabetic Rats

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dc.contributor.authorAkkoyun, Mahire Bayramoğlu
dc.contributor.authorBengü, A. Şükrü
dc.contributor.authorTemel, Yusuf
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorEkin, Suat
dc.contributor.authorÇiftci, Mehmet
dc.date.accessioned2024-12-24T19:16:36Z
dc.date.available2024-12-24T19:16:36Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study was aimed to study in vivo impacts of Rosa pisiformis (Christ) D.Sosn. (VANF F13827 END.) on some metabolic enzymes (G6PD, 6PGD, GR, TrxR and GST) in Streptozotocin (STZ) applied diabetic rats. 32 male Wistar albino rats divided four groups. Group I: Control, Group II:Streptozotocin, Group III: Rosa pisiformis and Group IV: Streptozotocin+Rosa pisiformis. Experimental study contunied for 30 days and enzyme activities were spectrophotometrically measured. R.p.fruit extract and STZ+R.p. fruit extract administrations increased Glucose 6-phosphate dehydrogenase (G6PD) activity meaningfully compared to control (p?0.001). 6-phosphogluconate dehydrogenase (6PGD) enzyme activity reduced in diabetes group compared to control, whereas it increased in R.p. fruit extract and STZ+R.p. fruit administered groups. Glutathione reductase (GR) activity raised in R.p. fruit administered group compared to control group meaningfully (p?0.001). Thioredoxin reductase (TrxR) activity decrease no statistical importance in diabetic rats compared control whereas this activity increased in Rosa pisiformis fruit extract group. Glutathione S-transferases (GST) enzyme activity reduction significantly in STZ group compared to control (p?0.05). As a result, It is thought that the fruits of Rosa pisiformis, which grows as an endemic species belonging to the Rosaceae family, may have a reducing or preventing effect on the 6PGD, TrxR and GST enzyme activities in rats by inhibiting caused by STZ.
dc.identifier.doi10.21597/jist.867807
dc.identifier.endpage2889
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue4
dc.identifier.startpage2880
dc.identifier.trdizinid1145114
dc.identifier.urihttps://doi.org/10.21597/jist.867807
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1145114
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4497
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectGST
dc.subjectG6PD
dc.subjectGR
dc.subject6PGD
dc.subjectRosa pisiformis
dc.subjectTrxR
dc.titleThe Effect of Rosa Pisiformis (Christ) D.Sosn on Some Metabolic Enzyme Activities in STZ Applied Diabetic Rats
dc.typeArticle

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