The Effect of Rosa Pisiformis (Christ) D.Sosn on Some Metabolic Enzyme Activities in STZ Applied Diabetic Rats
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study was aimed to study in vivo impacts of Rosa pisiformis (Christ) D.Sosn. (VANF F13827 END.) on some metabolic enzymes (G6PD, 6PGD, GR, TrxR and GST) in Streptozotocin (STZ) applied diabetic rats. 32 male Wistar albino rats divided four groups. Group I: Control, Group II:Streptozotocin, Group III: Rosa pisiformis and Group IV: Streptozotocin+Rosa pisiformis. Experimental study contunied for 30 days and enzyme activities were spectrophotometrically measured. R.p.fruit extract and STZ+R.p. fruit extract administrations increased Glucose 6-phosphate dehydrogenase (G6PD) activity meaningfully compared to control (p?0.001). 6-phosphogluconate dehydrogenase (6PGD) enzyme activity reduced in diabetes group compared to control, whereas it increased in R.p. fruit extract and STZ+R.p. fruit administered groups. Glutathione reductase (GR) activity raised in R.p. fruit administered group compared to control group meaningfully (p?0.001). Thioredoxin reductase (TrxR) activity decrease no statistical importance in diabetic rats compared control whereas this activity increased in Rosa pisiformis fruit extract group. Glutathione S-transferases (GST) enzyme activity reduction significantly in STZ group compared to control (p?0.05). As a result, It is thought that the fruits of Rosa pisiformis, which grows as an endemic species belonging to the Rosaceae family, may have a reducing or preventing effect on the 6PGD, TrxR and GST enzyme activities in rats by inhibiting caused by STZ.
Açıklama
Anahtar Kelimeler
GST, G6PD, GR, 6PGD, Rosa pisiformis, TrxR
Kaynak
Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
4
