Evaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques

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dc.contributor.authorDogac Oksen
dc.contributor.authorMuzaffer Aslan
dc.contributor.authorEbru Serin
dc.contributor.authorMuhammed Heja Gecit
dc.contributor.authorYunus Emre Yavuz
dc.contributor.authorEsra Yerlikaya Zerdali
dc.contributor.authorVeysel Oktay
dc.date.accessioned2025-04-14T12:07:09Z
dc.date.available2025-04-14T12:07:09Z
dc.date.issued2025-02-25
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground/Objectives: Highly active antiretroviral therapy (HAART) effectively suppresses viral load and aids immunological recovery in HIV patients, but may still lead to subclinical myocardial dysfunction. This study assesses left and right ventricular functions in patients on HAART containing abacavir, dolutegravir, and lamivudine using Tissue Doppler Imaging (TDI). Methods: This observational cross-sectional study involved 118 HIV-positive adults on HAART and 80 age- and gender-matched healthy controls. Comprehensive echocardiographic assessments, including TDI, were conducted to evaluate myocardial performance index (MPI) and isovolumic acceleration (IVA). Results: Conventional echocardiographic parameters showed no significant differences; however, TDI indicated significant impairments in ventricular functions in the HAART group, with increased MPI and decreased IVA (p < 0.001). Pulmonary artery pressures were also higher in the HIV group (p = 0.012). There was a strong positive correlation between MPI and HAART duration (r = 0.675, p = 0.002), and a negative correlation with CD4 count (r = −0.545, p = 0.006). Conclusions: TDI reveals significant subclinical ventricular dysfunction in HIV patients on HAART, correlating with therapy duration and immune status. These findings underscore the utility of TDI in detecting myocardial deterioration before clinical symptoms appear.
dc.identifier.citationOksen, D., Aslan, M., Serin, E., Gecit, M. H., Yavuz, Y. E., Zerdali, E. Y., & Oktay, V. (2025). Evaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques. Journal of Clinical Medicine, 14(5), 1534.
dc.identifier.doi10.3390/jcm14051534
dc.identifier.issn2077-0383
dc.identifier.issue5
dc.identifier.pmid40095518
dc.identifier.scopus2-s2.0-86000596735
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14051534
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8584
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslan, Muzaffer
dc.institutionauthorid0000-0002-2418-9472
dc.publisherMDPI AG
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman immunodeficiency virus
dc.subjectisovolumic acceleration
dc.subjectmyocardial performance index
dc.subjectsubclinical ventricular dysfunction
dc.subjecttissue Doppler imaging
dc.titleEvaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques
dc.typejournal-article
oaire.citation.issue5
oaire.citation.volume14

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