Neuroprotective Potential of a Novel Soluble Guanylate Cyclase Stimulator the Riociguat Alone or in a Combination Manner with Resveratrol in Experimental Stroke Model in Rats

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dc.contributor.authorAslanoglu, Baris
dc.contributor.authorKaya, Seval
dc.contributor.authorGunara, Sezer Onur
dc.contributor.authorAtlas, Burak
dc.contributor.authorSeker, Ugur
dc.contributor.authorGuzel, Baris Can
dc.contributor.authorTuran, Yahya
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study we aimed to examine the effect of novel vasodilatory drug Riociguat co-administration along resveratrol to recover neurodegeneration in experimental stroke injury. For that purpose, thirty-five adult female rats were divided into groups five (Control, MCAO, MCAO + R, MCAO + BAY, MCAO + C) of seven animals in each. Animals in Control group did not expose to any application during the experiment and sacrificed at the end of the study. Rats in the rest groups exposed to middle cerebral artery occlusionO) (MCAinduced ischemic stroke. MCAO + R group received 30 mg/kg resveratrol, and MCAO + BAY group received 10 mg/kg Riociguat. The MCAO + C group received both drugs simultaneously. The drugs were administered just before the reperfusion, and the additional e doses weradministered 24h, and 48h hours of reperfusion. All animals in this study were sacrificed at the 72nd hour of experiment. Total brainsreceived were for analysis. Results of this experiment indicated that MCAO led to severe injury in cerebral structure. Bax, IL-6 and IL-1 ss levelstissue were upregulated, but anti-apoptotic Bcl-2 immunoexpression was suppressed (p<0.05). In resveratrol and Riociguat treated animals, the neurodegenerations and apoptosis and inflammation associated protein expressions were improved compared to MCAO group, mosbut the success was obtained in combined treatment exposed animals in MCAO + C group. This study indicated that the novel solubleate guany cyclase stimulator Riociguat is not only a potent neuroprotective drug in MCAO induced stroke, but also synergistic administratio of Riociguat along with resveratrol have potential to increase the neuroprotective effect of resveratrol in experimental cerebral strokeosed rats.
dc.description.sponsorshipDicle University Scientific Research and Project Coordinatorship [TIP.21.013]
dc.description.sponsorshipThis study was financially supported by Dicle University Scientific Research and Project Coordinatorship with grant no: TIP.21.013.
dc.identifier.endpage990
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85203050073
dc.identifier.scopusqualityQ3
dc.identifier.startpage984
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8128
dc.identifier.volume42
dc.identifier.wosWOS:001308286200015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Chilena Anatomia
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectStroke
dc.subjectResveratrol
dc.subjectRiociguat
dc.subjectApoptosis
dc.subjectInflammation.
dc.titleNeuroprotective Potential of a Novel Soluble Guanylate Cyclase Stimulator the Riociguat Alone or in a Combination Manner with Resveratrol in Experimental Stroke Model in Rats
dc.title.alternativePotencial Neuroprotector del Novedoso Estimulador de Guanilato Ciclasa Soluble, el Riociguat solo o en Combinación con Resveratrol en un Modelo Experimental de Ataque Cerebrovascular en Ratas
dc.typeArticle

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