PROTECTIVE EFFECT OF ELLAGIC ACID AGAINST CARBON TETRACHLORIDE (CCl4) - INDUCED OXIDATIVE BRAIN INJURY IN RATS

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dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorBengu, Aydin Sukru
dc.contributor.authorUlucan, Aykut
dc.contributor.authorBayramoglu-Akkoyun, Mahire
dc.contributor.authorArihan, Okan
dc.date.accessioned2024-12-24T19:33:21Z
dc.date.available2024-12-24T19:33:21Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate protective effects of Ellagic acid in rats which have brain damage formed with carbon tetrachloride (CCl4). 28 male Wistar albino rats were separated into 4 groups as Control, CCl4., Ellagic acid and CCl4+ Ellagic acid. From the brain tissue homogenate malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), gluthation peroxidase (GSH-Px), catalase (CAT) levels were measured and routine histopathological investigation was performed. An increase in MDA level (p<0.01) whereas a decrease in CAT, GSH-Px, SOD (p<0.01) and GSH (p<0.05) levels in CCl4 administered group compared to control was observed. In our study, in the control and Ellagic acid administered groups, no microscopic findings were observed in the brain, while severe lesions were seen in the CCl4 administered group and only mild congestion lesions were seen in the CCl4 + Ellagic acid group. Results of this study suggest a protection by ellagic acid against CCl4 induced brain damage. This protection is possibly via induction of antioxidant protective mechanism which is shown both by biochemical and histopathological methods.
dc.identifier.endpage3155
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue5
dc.identifier.startpage3148
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8100
dc.identifier.volume27
dc.identifier.wosWOS:000436522600065
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectBrain damage
dc.subjectCarbon tetrachloride
dc.subjectEllagic Acid
dc.subjectRat
dc.titlePROTECTIVE EFFECT OF ELLAGIC ACID AGAINST CARBON TETRACHLORIDE (CCl4) - INDUCED OXIDATIVE BRAIN INJURY IN RATS
dc.typeArticle

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