PROTECTIVE EFFECT OF ELLAGIC ACID AGAINST CARBON TETRACHLORIDE (CCl4) - INDUCED OXIDATIVE BRAIN INJURY IN RATS
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, it was aimed to investigate protective effects of Ellagic acid in rats which have brain damage formed with carbon tetrachloride (CCl4). 28 male Wistar albino rats were separated into 4 groups as Control, CCl4., Ellagic acid and CCl4+ Ellagic acid. From the brain tissue homogenate malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), gluthation peroxidase (GSH-Px), catalase (CAT) levels were measured and routine histopathological investigation was performed. An increase in MDA level (p<0.01) whereas a decrease in CAT, GSH-Px, SOD (p<0.01) and GSH (p<0.05) levels in CCl4 administered group compared to control was observed. In our study, in the control and Ellagic acid administered groups, no microscopic findings were observed in the brain, while severe lesions were seen in the CCl4 administered group and only mild congestion lesions were seen in the CCl4 + Ellagic acid group. Results of this study suggest a protection by ellagic acid against CCl4 induced brain damage. This protection is possibly via induction of antioxidant protective mechanism which is shown both by biochemical and histopathological methods.
Açıklama
Anahtar Kelimeler
Brain damage, Carbon tetrachloride, Ellagic Acid, Rat
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
27
Sayı
5
