IN VITRO INHIBITION OF PURIFIED HUMAN CARBONIC ANHYDRASE I AND II BY NOVEL FLUORENE DERIVATIVES

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dc.authoridGencer, Nahit/0000-0001-7092-8857
dc.authoridKAYA, Mustafa Oguzhan/0000-0002-8592-1567
dc.authoridARSLAN, Mustafa/0000-0003-0796-4374
dc.contributor.authorDemirhan, Hulya
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKaya, Mustafa Oguzhan
dc.contributor.authorKaya, Yesim
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2014
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 mu M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 mu M) for inhibition of hCA II.
dc.description.sponsorshipResearch Fund of the Sakarya University; [2012-02-04-043]
dc.description.sponsorshipThis work was supported by the Research Fund of the Sakarya University. Project Number: 2012-02-04-043.
dc.identifier.issn1857-5552
dc.identifier.issn1857-5625
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8129
dc.identifier.volume33
dc.identifier.wosWOS:000345285100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSoc Chemists Technologists Madeconia
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subject9-benzylidene-9H-fluorene
dc.subjecturea
dc.subjectthiourea
dc.subjectcarbonic anhydrase
dc.subjectinhibition
dc.titleIN VITRO INHIBITION OF PURIFIED HUMAN CARBONIC ANHYDRASE I AND II BY NOVEL FLUORENE DERIVATIVES
dc.typeArticle

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