IN VITRO INHIBITION OF PURIFIED HUMAN CARBONIC ANHYDRASE I AND II BY NOVEL FLUORENE DERIVATIVES
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Chemists Technologists Madeconia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, 9-benzylidene-9H-fluorene-substituted urea (5a-p) and thiourea derivatives (5q-v) were synthesized and their inhibitory effects on the activity of human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II were purified from human erythrocytes using a Sepharose 4B-L-tyrosine-sulphanilamide affinity column. All the synthesized compounds inhibited the activity of the hCA I and II isoenzymes. Among the synthesized compounds, 5f was found to be the most active (IC50 = 21.4 mu M) for inhibition of hCA I and 5s was the most active (IC50 = 25.3 mu M) for inhibition of hCA II.
Açıklama
Anahtar Kelimeler
9-benzylidene-9H-fluorene, urea, thiourea, carbonic anhydrase, inhibition
Kaynak
Macedonian Journal of Chemistry and Chemical Engineering
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
33
Sayı
2
