The Protective Effects of Boric Acid against Acrylamide-induced Pulmonary Damage in Rats

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dc.authoridONUR, SUZAN/0000-0001-8145-6090
dc.contributor.authorOnur, Suzan
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:30:52Z
dc.date.available2024-12-24T19:30:52Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThe purpose of this study was to investigate whether boric acid (BA) can reduce the acute lung injury caused by acrylamide (ACR) in rats. ACR was orally given to produce acute lung damage. Group 1 (saline), Group 2 (ACR, 38.27 mg/kg)), Group 3 (20 mg/kg BA), Group 4 (10 mg/kg BA+ACR), and Group 5 (20 mg/kg BA+ACR) were five equal groups of thirty rats. Lungs were taken for histological analysis, immunohistochemical staining and biochemical evaluations after the experimental trial. Malondialdehyde (MDA) levels, a marker of lipid peroxidation and oxidative stress, increased after ACR administration. Nevertheless, it caused the reduction of glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in lungs. The administration of BA efficiently inhibited the activities of CAT, GSH, SOD, and GPx in lung tissue and protected the lipid peroxidation caused by ACR. Moreover, increased expression of Bax, Caspase-3 and reduced Bcl-2 were found in the lung tissue of rats given ACR, which indicated enhanced congestion, inflammation, alveolar damage, and apoptosis. Interestingly, in rats given ACR injections, BA enhanced the expression of indicators of histological damage and lung injury. These results indicate the efficacy of BA treatment in preventing lipid peroxidation caused by ACR and reducing the negative effects on antioxidant capacity.
dc.identifier.doi10.29261/pakvetj/2024.229
dc.identifier.issn0253-8318
dc.identifier.issn2074-7764
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85207273415
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.29261/pakvetj/2024.229
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7716
dc.identifier.volume44
dc.identifier.wosWOS:001338554500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Agriculture, Fac Veterinary Science
dc.relation.ispartofPakistan Veterinary Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectKey Acrylamide
dc.subjectAntioxidant
dc.subjectBiochemical toxicity
dc.subjectBoric acid
dc.subjectPulmonary damage
dc.titleThe Protective Effects of Boric Acid against Acrylamide-induced Pulmonary Damage in Rats
dc.typeArticle

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