Evaluation of the Antioxidant, Antidiabetic and Anti-Alzheimer Effects of Capsella bursa-pastoris-Polyphenolic Profiling by LC-MS/MS
| dc.authorid | https://orcid.org/0000-0002-0255-9727 | |
| dc.contributor.author | İlhami Gülçin | |
| dc.contributor.author | Hasan Karageçili | |
| dc.contributor.author | Tuğba Polat | |
| dc.contributor.author | Mustafa Abdullah Yılmaz | |
| dc.contributor.author | Mehmet Fidan | |
| dc.contributor.author | Cengiz Karaismailoğlu | |
| dc.date.accessioned | 2025-01-13T08:34:07Z | |
| dc.date.available | 2025-01-13T08:34:07Z | |
| dc.date.issued | 2024-12-26 | |
| dc.department | Fakülteler, Fen-Edebiyat Fakültesi, Biyoloji Bölümü | |
| dc.description.abstract | Capsella bursa-pastoris species of the Capsella herb were examined in this study for sreening of antioxidant, antidiabetic and anti-Alzheimer effects. Traditionally, people consumed C. bursa-pastoris against famine and satisfy their hunger. C. bursa-pastoris species have been shown to have utility as food, medicine, and industrial materials after extensive investigation. The antioxidant properties of methanol and water extracts of C. bursa-pastoris species were assessed using; Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ), ferric (Fe3+), and cupric (Cu2+) iobs reducing assays, as well as 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) and N,N-dimethyl-p-phenylenediamine (DMPD) radical scavenging activities. The antioxidant and reducing capacity of C. bursa-pastoris species aerial parts water and methanol extracts were compared with standard antioxidants. The phenolic and flavonoid contents in methanol and water extracts of C. bursa-pastoris species were measured 6.86 to 12.00 mg GAE/g and 61.67 to 145.0 mg QE/g, respectively. The inhibitions of effects of water and methanol extract of C. bursa-pastoris species against α-amylase, and acetylcholinesterase (AChE) enzymes were investigated. The IC50 values were found as 168.6 to 238.6 μg/mL against α-amylase and 19.0 to 20.9 μg/mL against AChE. The number of fenolik compounds in both extracts of C. bursa-pastoris species were recorded using LC-MS/MS. The major phenolic and flavonoid components detected in methanol extract of C. bursa-pastoris were quinic acid (22.629 mg/g), chlorogenic acid (3.211 mg/g), rutin (1.930 mg/g), hesperidin (0.893 mg/g), and isoquercitrin (0.783 mg/g). In a similar order, quinic acid (11.356 mg/g), cyranoside (9.463 mg/g), chlorogenic acid (6.072 mg/g), hesperidin (5.912 mg/g), and isoquercitrin (5.364 mg/g) were found as plentyfull pehenolic antioxidants in methanolic extract. The results clearly demonstrated that polyphenolic antioxidants-rich ingredients of the aerial parts of C. bursa-pastoris species are biological phenolic comounds have persuasive usage in the medication of diabetes and Alzheimer's diseases. | |
| dc.identifier.citation | Karageçili, H., Polat, T., Yılmaz, M. A., Fidan, M., Karaismailoğlu, C., & Gülçin, İ. (2024). Evaluation of the Antioxidant, Antidiabetic and Anti-Alzheimer Effects of Capsella bursa-pastoris-Polyphenolic Profiling by LC-MS/MS. Records of Natural Products, 18(6), 662. | |
| dc.identifier.doi | 10.25135/rnp.489.2410.3353 | |
| dc.identifier.endpage | 662 | |
| dc.identifier.issn | 1307-6167 | |
| dc.identifier.issue | 6 | |
| dc.identifier.startpage | 643 | |
| dc.identifier.uri | https://10.25135/rnp.489.2410.3353 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12604/8438 | |
| dc.identifier.volume | 18 | |
| dc.identifier.wosquality | Q3 | |
| dc.institutionauthor | Karageçeli, Hasan | |
| dc.institutionauthor | Fidan, Mehmet | |
| dc.language.iso | en | |
| dc.publisher | ACG Publications | |
| dc.relation.ispartof | Records of Natural Products | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | acetylcholinesterase | |
| dc.subject | antioxidant activity | |
| dc.subject | Capsella bursa-pastoris | |
| dc.subject | enzyme inhibition | |
| dc.subject | phenolic compounds | |
| dc.subject | α-amylase | |
| dc.title | Evaluation of the Antioxidant, Antidiabetic and Anti-Alzheimer Effects of Capsella bursa-pastoris-Polyphenolic Profiling by LC-MS/MS | |
| dc.type | journal-article | |
| oaire.citation.issue | 6 |
