ELECTROCHEMICAL BEHAVIOR OF THE ANTINEOPLASTIC AGENT ETOPOSIDE AT A GRAPHENE-BASED MODIFIED ELECTRODE: ITS SQUARE-WAVE ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION IN THE PHARMACEUTICAL FORMULATIONS

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dc.authoridSAKA, Cafer/0000-0003-2534-5921
dc.authoridyardim, yavuz/0000-0002-9587-096X
dc.contributor.authorTalay Pinar, Pinar
dc.contributor.authorSaka, Cafer
dc.contributor.authorYardim, Yavuz
dc.date.accessioned2024-12-24T19:33:12Z
dc.date.available2024-12-24T19:33:12Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractAn electrochemical sensor based on the graphene (GR) was prepared, and used for the determination of etoposide (ETO). The electrochemical behaviors of this compound on GR modified glassy carbon electrode (GR/GCE) were investigated by cyclic voltammetry and square-wave adsorptive stripping voltammetry (SWAdSV). Using SWAdSV, a linear calibration curve was obtained for ETO determination in 0.1 M Britton-Robinson (BR, pH 4.0) buffer solution at +0.56 V (vs. Ag/AgCl) (after 30 s accumulation at 0.1 V). A linear relationship was found between peak currents and the concentration of ETO within 0.025 to 0.5 mu g mL(-1), with a detection limit of 0.0023 mu g mL(-1). The developed method was successfully applied to the determination of ETO in the pharmaceutical formulations with good recoveries.
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Foundation [FBA-2017-5872]
dc.description.sponsorshipThe authors gratefully acknowledge financial support from the Van Yuzuncu Yil University Scientific Research Foundation (Project number: FBA-2017-5872).
dc.identifier.endpage1156
dc.identifier.issn0035-3930
dc.identifier.issue12
dc.identifier.startpage1149
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8020
dc.identifier.volume63
dc.identifier.wosWOS:000461805700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofRevue Roumaine De Chimie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectetoposide
dc.subjectsquare-wave adsorptive stripping voltammetry
dc.subjectgraphene modified glassy carbon electrode
dc.subjectpharmaceutical formulations
dc.titleELECTROCHEMICAL BEHAVIOR OF THE ANTINEOPLASTIC AGENT ETOPOSIDE AT A GRAPHENE-BASED MODIFIED ELECTRODE: ITS SQUARE-WAVE ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION IN THE PHARMACEUTICAL FORMULATIONS
dc.typeArticle

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