ELECTROCHEMICAL BEHAVIOR OF THE ANTINEOPLASTIC AGENT ETOPOSIDE AT A GRAPHENE-BASED MODIFIED ELECTRODE: ITS SQUARE-WAVE ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION IN THE PHARMACEUTICAL FORMULATIONS
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Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editura Acad Romane
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An electrochemical sensor based on the graphene (GR) was prepared, and used for the determination of etoposide (ETO). The electrochemical behaviors of this compound on GR modified glassy carbon electrode (GR/GCE) were investigated by cyclic voltammetry and square-wave adsorptive stripping voltammetry (SWAdSV). Using SWAdSV, a linear calibration curve was obtained for ETO determination in 0.1 M Britton-Robinson (BR, pH 4.0) buffer solution at +0.56 V (vs. Ag/AgCl) (after 30 s accumulation at 0.1 V). A linear relationship was found between peak currents and the concentration of ETO within 0.025 to 0.5 mu g mL(-1), with a detection limit of 0.0023 mu g mL(-1). The developed method was successfully applied to the determination of ETO in the pharmaceutical formulations with good recoveries.
Açıklama
Anahtar Kelimeler
etoposide, square-wave adsorptive stripping voltammetry, graphene modified glassy carbon electrode, pharmaceutical formulations
Kaynak
Revue Roumaine De Chimie
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
63
Sayı
12
