Comprehensively Revealing the Profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma Effects

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dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.authoridKARAGECILI, HASAN/0000-0001-6912-3998
dc.contributor.authorKaragecili, Hasan
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorArik, Mustafa
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-12-24T19:30:48Z
dc.date.available2024-12-24T19:30:48Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractPistacia species containing turpentine which has protective effects and used as a medicine against diabetes, and infections for a long time. To interpret the antioxidant capacities of turpentine from Pistacia vera L. cv. Siirt, 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS(center dot+)) and 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH center dot), Fe3+- 2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) and Cu2+ reducing ability were studied and compared to reference antioxidants of BHT, BHA, alpha-Tocopherol, and Trolox. The IC50 of turpentine for ABTS(center dot+) and DPPH center dot scavenging capacities were determined to be lower than reference antioxidant standards as 231.1 mu g/mL and 346.6 mu g/mL, consequently. The total flavonoid and phenolic contents in turpentine were measured as 12.5 mg GAE/g and 38.852 mg QE/g, respectively. For determination of antidiabetic, anti-Alzheimer, and antiglaucoma effects of turpentine, acetylcholinesterase (AChE), alpha-glycosidase and carbonic anhydrase II (hCA II) enzymes inhibition abilities of turpentine were performed. The IC50 values of turpentine extract against alpha-glycosidase, hCA II, and AChE enzymes were found as 2.04, 3.59 and 14.6 mu g/mL, respectively. The quantity of protocatechuic acid and naringenin were determined using LC-MS/MS against 53 standards. The results clearly demonstrated polyphenolics in P. vera L. cv. Siirt turpentine is a natural product has potential usage in amelioration of glaucoma, AD, diabetes, and epilepsy.
dc.description.sponsorshipKing Saud University, Saudi Arabia [RSP-2023/59]
dc.description.sponsorshipS. Alwasel would like to extend his sincere appreciation to the Researchers Supporting Project (RSP-2023/59), King Saud University, Saudi Arabia, for support.
dc.identifier.doi10.25135/rnp.410.2305.2787
dc.identifier.endpage937
dc.identifier.issn1307-6167
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85171523228
dc.identifier.scopusqualityQ2
dc.identifier.startpage918
dc.identifier.urihttps://doi.org/10.25135/rnp.410.2305.2787
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7688
dc.identifier.volume17
dc.identifier.wosWOS:001258136200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAcg Publications
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectPhenolic compounds
dc.subjectturpentine
dc.subjectantioxidant
dc.subjecta-glycosidase
dc.subjectacetylcholinesterase
dc.subjectcarbonic anhydrase
dc.titleComprehensively Revealing the Profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma Effects
dc.typeArticle

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