Design, spectroscopic properties and effects of novel catechol spiroborates derived from Schiff bases in the antioxidant, antibacterial and DNA binding activity

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dc.authoridSoylemez, Rahime/0000-0003-3287-9243
dc.contributor.authorKilic, Ahmet
dc.contributor.authorSoylemez, Rahime
dc.contributor.authorOkumu, Veysi
dc.date.accessioned2024-12-24T19:27:28Z
dc.date.available2024-12-24T19:27:28Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractNovel catechol spiroborates (L(1-5)B) were prepared from the reaction of the corresponding Schiff base (L(1-5)H) ligands, boric acid, and 3,5-di-ten-butyl catechol under favorable reaction conditions. The synthesized all compounds were characterized by NMR spectra, FT-IR spectra, UV-Vis spectra, LC-MS/MS spectra, fluorescence spectra, elemental analysis as well as the melting point. The optical properties of the Schiff base ligands and catechol spiroborates were investigated using - and fluorescence spectra in the C2H5OH. The antioxidant activities of newly synthesized Schiff base ligands and their catechol spiroborates were investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability and reducing power ability. Among the synthesized catechol spiroborates, (L2B) exhibited the maximum radical scavenging (91.5 +/- 2.11%) and reducing power activity (0.654 +/- 0.015) at a concentration of 200.0 mu g/mL. Antibacterial activity was determined using 3 Gram positive and 2 Gram negative bacteria by disk diffusion method. Schiff base (L2H) was found to be effective against all test bacteria used. Besides, the DNA binding activity of the catechol spiroborates was determined using Calf Thymus DNA, and the DNA cleavage activity was determined using pBR-322 plasmid DNA by agarose gel electrophoresis method. (C) 2021 Elsevier B.V. All rights reserved.
dc.description.sponsorshipResearch Fund of Harran Uni-versity (HUBAP Project) [20 0 06]
dc.description.sponsorshipThis work was supported by the Research Fund of Harran Uni-versity (HUBAP Project No. 20 0 06)
dc.identifier.doi10.1016/j.jorganchem.2021.122228
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85121792996
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2021.122228
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6637
dc.identifier.volume960
dc.identifier.wosWOS:000767849200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectSchiff base
dc.subjectSpiroborates
dc.subjectOptical studies
dc.subjectAntibacterial and antioxidant activity
dc.subjectDNA cleavage activity
dc.titleDesign, spectroscopic properties and effects of novel catechol spiroborates derived from Schiff bases in the antioxidant, antibacterial and DNA binding activity
dc.typeArticle

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