The impact of ambroxol on the anti-inflammatory effect of azithromycin in lung tissue

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dc.authoridBAHCIVAN, Emre/0000-0002-4415-1738
dc.contributor.authorEr, Ayse
dc.contributor.authorDik, Burak
dc.contributor.authorCoskun, Devran
dc.contributor.authorFaki, Hatice Eser
dc.contributor.authorBahcivan, Emre
dc.date.accessioned2024-12-24T19:30:46Z
dc.date.available2024-12-24T19:30:46Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this study was to compare the effects of two different doses of ambroxol (AMB) co-administered with azithromycin (AZIT) on the concentrations of bronchoalveolar lavage fluid (BALF) cytokines and serum biochemical parameters in an lipopolysaccharide (LPS)-induced acute lung injury mouse model. A total of 78 male Swiss albino mice were used for this investigation. After six mice had been separated as the control group (0 hours), the remaining animals were divided into the following three equal groups: LPS, LPS+AZIT+AMB30 and LPS+AZIT+AMB70. LPS, AZIT and AMB were administered intraperitoneally. BALF and serum samples were collected before (0 hour) and after applications at 4, 8, 16 and 24 hours under general anaesthesia, and then all mice were euthanised by cervical dislocation. Concentrations of tumor necrosis factor (TNF)alpha, interleukin (IL)-6 and IL-10 in BALF and aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine concentrations in serum were determined. Elevated TNF alpha and IL-6 concentrations in the LPS group were prevented at 8 and 16 hours in LPS+AZIT+AMB30 group. In addition, both treatment groups inhibited elevated IL-6 concentrations in the LPS group at 16 hours. LPS+AZIT+AMB30 and LPS+AZIT+AMB70 increased IL-10 concentrations at 16 and 4 hours, respectively. LPS caused significant elevations in urea concentrations at all sampling times and statistical fluctuations in other parameters at different sampling times. The increased ALP concentration in LPS group decreased in the treatment groups at 8 hours. In conclusion, the combination of low-dose AMB and AZIT may achieve beneficial effects in pulmonary infections by influencing the cytokine network.
dc.identifier.doi10.24099/vet.arhiv.1197
dc.identifier.endpage671
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85125100862
dc.identifier.scopusqualityQ4
dc.identifier.startpage665
dc.identifier.urihttps://doi.org/10.24099/vet.arhiv.1197
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7667
dc.identifier.volume91
dc.identifier.wosWOS:000756517000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Zagreb Vet Faculty
dc.relation.ispartofVeterinarski Arhiv
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectacute lung injury
dc.subjectambroxol
dc.subjectazithromycin
dc.subjectBALF
dc.subjectcytokine
dc.titleThe impact of ambroxol on the anti-inflammatory effect of azithromycin in lung tissue
dc.title.alternativeUtjecaj ambroksola na protuupalni u?inak azitromicina u plu?nom tkivu.
dc.typeArticle

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