Effect of Kefir on Increased Apoptosis in Liver and Kidney in Cisplatin Toxicity

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dc.authoridSoyler, Gizem/0000-0002-8192-906X
dc.authoridSayiner, Serkan/0000-0002-3297-5369
dc.authoridSah, Huseyin/0000-0003-0480-1609
dc.contributor.authorSah, Huseyin
dc.contributor.authorGulmez, Nurhayat
dc.contributor.authorSoyler, Gizem
dc.contributor.authorSayiner, Serkan
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorKukner, Aysel
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractCisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an essential probiotic and functional food, on liver and kidney damage induced by cisplatin. Wistar albino rats were divided into four groups: Control, Cisplatin (single dose of 7 mg/kg, intraperitoneal), Kefir (2 ml/d, 7 d, oral gavage), and Cisplatin+Kefir (CK). At the end of day 7, animals were euthanized. Blood, kidney, and liver tissue samples were collected. For both tissues, biochemically ALT, AST, Urea, Creatine; histomorphologically, hematoxylin-eosin, Masson's Trichrome, and immunohistochemical staining of caspase-3, a marker of apoptosis, were performed. Serum urea and creatinine levels of the Cisplatin group were significantly higher than the Control group (p<0.05). In the CK group, kefir consumption decreased urea and creatinin levels approached to Control and Kefir groups. Cisplatin resulted in higher ALT and AST activities, indicating hepatocellular damage, compared to the Control group (p<0.05). Kefir consumption decreased ALT activities approached to both the Control and Kefir group. Histomorphological observations were in agreement biochemical results. In liver and kidney tissues, structural damage was observed with an increase in collagen fibers in the Cisplatin group, and Caspase-3 activity was immunohistochemically higher than in the other groups. In the CK group, collagen fiber increase, structural damage, and Caspase-3 activities were less than in the Cisplatin group. Kefir consumption alleviated liver and kidney damage. However, more research is required to understand such effect of kefir better.
dc.description.sponsorshipNear East University [SAG-2019-2-027]
dc.description.sponsorshipThe authors appreciate the research support provided by a grant from the Near East University, Nicosia/Cyprus (grant no. SAG-2019-2-027).
dc.identifier.endpage488
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85131058511
dc.identifier.scopusqualityQ3
dc.identifier.startpage480
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8141
dc.identifier.volume40
dc.identifier.wosWOS:000800856600032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Chilena Anatomia
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCisplatin
dc.subjectKefir
dc.subjectUrea
dc.subjectLiver
dc.subjectKidney
dc.titleEffect of Kefir on Increased Apoptosis in Liver and Kidney in Cisplatin Toxicity
dc.title.alternativeEfecto del Kéfir sobre el Aumento de la Apoptosis en el Hígado y los Riñones en la Toxicidad del Cisplatino
dc.typeArticle

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