Analysis and controllability of diabetes model for experimental data by using fractional operator
[ X ]
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diabetes is a silent illness that is endangering public health in society. Diabetes is a chronic disease affecting millions of people worldwide, and understanding the underlying mechanisms of glucose homeostasis is crucial for managing this condition. Diabetes is a significant public health issue due to the early morbidity, mortality, shortened life expectancy, and financial and other expenses to the patient, their careers, and the health care system. In this study, we propose a mathematical model consisting of fl-cells, insulin, glucose, and growth hormone that incorporates the fractional operator. Using the Lyapunov function, we treated a global stability analysis and investigated the impact of a new wave of dynamical transmission on the equilibrium points of the second derivative. With the Lipschitz criteria and linear growth, the exact singular solution for the proposed model has been determined. Furthermore, we present a detailed analysis of infections, and numerical simulations are conducted using the Mittag-Leffler Kernel mathematical framework to illustrate the theoretical conclusions for various orders of the fractional derivative. Controllability and observability of the linear system are treated for close loop design to check the relation between the glucose and insulin systems. Overall, our results provide a comprehensive understanding of glucose homeostasis and its underlying mechanisms, contributing to the development of effective diabetes management strategies. The proposed model and mathematical framework offer a valuable tool for investigating complex systems and phenomena, with applications beyond the field of diabetes research and helpful to designing the closed loop for the glucose-insulin system.
Açıklama
Anahtar Kelimeler
Diabetes model, Lyapunov stability, Fractal-fractional derivative, Controllability, Linear growth, Close loop design
Kaynak
Mathematics and Computers in Simulation
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
218
