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Öğe Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats(Springer Science and Business Media LLC, 2025-04-07) Faysal Selimoğlu; Mustafa Cengiz; Canan Vejselova Sezer; Adnan Ayhanci; Fatma Gür; Özge Yıldırım; Bahri Gür; Ahmet MusmulThe purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.Öğe Different essential oils can inhibit Candida albicans biofilm formation on acrylic resin by suppressing aspartic proteinase: In vitro and in silico approaches(Springer Science and Business Media LLC, 2025-01-28) Nurdan Polat Sağsöz; Leyla Güven; Bahri Gür; Canan Vejselova Sezer; Mustafa Cengiz; Figen Orhan; Özlem BarışIntroduction: Cymbopogon martini, Syzygium aromaticum, and Cupressus sempervirens are used for antimicrobial purposes in the worldwide. Both their extracts and essential oil contents are rich in active ingredients. Objective: The aim of this study was to investigate the inhibitory effect of Cymbopogon martini essential oil (CMEO), Syzygium aromaticum essential oil (SAEO) and Cupressus sempervirens essential oil (CSEO) on Candida albicans biofilm formation on heat-polymerized polymethyl methacrylate (PMMA) samples in vitro and in silico. Materials and methods: Essential oil contents with anticandidal potential were determined by Gas Chromatography-Mass Spectrometry. Following C. albicans adhesion, PMMA samples were treated independently with Corega® and each essential oil. The anticandidal activity of the essential oils was determined by spectrophotometric absorbance measurement at 600 nm, taking into account the cultures of each sample. The cytotoxicity evaluation of essential oils was performed by MTT Colorimetric assay. The software package AutoDockTools (1.5.6) was used for the in silico studies. The effect of essential oil content on the inhibition of Secreted aspartic proteinase (SAP2) was evaluated considering the Ligand@SAP2 complex formation. Results: 2% of CMEO and 5% of SAEO exhibited higher anticandidal activity than Corega® (p < 0.05), whereas Corega® had higher anticandidal activity than 2% and 5% of CSEO (p < 0.05). The cytotoxicity of essential oils on NIH/3T3 cells after 24 h was found to be 2.41 for CSEO, 2.84 for CMEO, and 2.85 µg/mL for SAEO. The results of the in silico study showed that citronellol from CMEO, chavibetol (m-eugenol) from SAEO and β-pinene from CSEO each had the highest effect on the inhibition of SAP2. The highest binding affinity value was found for citronellol at -5.3 kcal/mol. Conclusions: The biofilm formation of C. albicans onto acrylic resin was inhibited by CMEO, SAEO and CSEO at a concentration of 2% through in vitro assay. The most effective inhibition was determined to be due to citronellol in CMEO through in silico analysis.Öğe Eco-friendly biosynthesized silver, copper, and nickel nanoparticles mediated Rheum ribes: Assessment of their cytotoxicity and antimicrobial activity(Elsevier BV, 2025-02) Bahri Gür; Mustafa Cengiz; Canan Vejselova Sezer; Orhan Baytar; Ömer Şahin; Adnan Ayhanci; Hatice Mehtap KutluBackground: The green synthesis of metallic nanoparticles has recently become a research area of increasing interest due to their potential applications in nanomedicine. Aim of study: This study aimed to investigate, for the first time, the anticancer properties of silver nanoparticles (Ag-NPs), copper oxide nanoparticles (CuO-NPs), and nickel oxide nanoparticles (NiO-NPs) on A549 and Beas-2B cell lines, as well as their antibacterial efficacy against Escherichia coli and Staphylococcus aureus strains, synthesized through a green synthesis approach utilizing Rheum ribes plant extract. Methodology: The current study introduces a sustainable and environmentally friendly method for the biosynthesis of Ag-NPs, CuO-NPs, and NiO-NPs utilizing the aqueous extract of Rhubarb (Rheum ribes). The spectroscopic and morphological properties of the Ag-NPs, CuO-NPs, and NiO-NPs obtained from the Rheum ribes extract were confirmed using different analytical techniques. Results: The Ag-NPs, CuO-NPs, and NiO-NPs exhibited different morphology with a size of about 7.90, 12.0, and 12.63 nm, respectively, and were free of impurities and highly stable particles. In addition, the NPs were further investigated for their anticancer and antibacterial properties. The anticancer effects of the NPs were assessed using the MTT assay and confocal microscopy in non-small cell lung cancer (A549) and healthy lung (Beas-2B) cells. The study results demonstrated that Ag-NPs, CuO-NPs, and NiO-NPs had cytotoxic effects on A549 cells that were concentration-based, having IC50 values of 4.16, 21.28, and 37.68 μg/mL, in that order. Additionally, it was observed that the above-mentioned NPs exhibited strong activity against bacteria. Conclusions: The nanoparticles derived from Rheum ribes extract appear to hold great potential as a class of nano-biomaterials intended for usage in biological fields.Öğe Predictive Value of Plasma Zonulin Levels during Early Gestational Weeks in Gestational Diabetes Mellitus(Galenos Yayinevi, 2024-12-25) Celal Cengiz; Lebriz Hale Aktün Tamer; Volkan Ülker; Mustafa Cengiz; İsa Aykut ÖzdemirObjective: This study aimed to determine the impact and predictive utility of serum zonulin levels measured between 11-14 weeks of gestation and 75-g oral glucose tolerance test (OGTT) testing between 24-28 weeks of gestation in predicting patients diagnosed with gestational diabetes mellitus (GDM). Methods: The study included 209 pregnant women at 11-14 weeks of gestation. Among the pregnant women who presented to the Obstetrics and Gynecology Outpatient Department of İstanbul Medipol Mega Hospital, those who could not be reached due to the covid pandemic (69), aborted (4), diagnosed with chromosomal abnormalities in the fetus (3), and those who withdrew from the study (4) were excluded from the study. The study group included 48 pregnant women diagnosed with GDM at 24-28 weeks of gestation. On the other hand, the control group was formed by randomly selecting 40 pregnant women from 81 pregnant women who were not diagnosed with GDM due to the lack of a kit using a computer-based program. GDM was diagnosed using an OGTT performed between 24 and 28 weeks of gestation according to the International Association of Diabetes and Pregnancy Study Groups criteria. Plasma zonulin levels were measured using enzyme-linked immunosorbent assay. Results: When zonulin (ng/mL) and body mass index (BMI) (kg/m2) values were compared between the study and control groups, a significant correlation was found between zonulin (35.77±8.79 (ng/mL), 29.76±6.96 (ng/mL), p=0.01) and BMI (kg/m2) (26.02±2.39, 24.78±2.7 (kg/m2), p=0.032). In addition, a correlation analysis showed a significant positive correlation between plasma zonulin level and first-hour OGTT. Conclusion: The findings of our research indicate that zonulin has the potential to function as a non-invasive biomarker of GDM development. More extensive research is required on this topic.Öğe Protective Effect of Escin Against Kidney Injury: Histopathological and Biochemical Evaluations(MDPI AG, 2024-11-25) Mustafa Cengiz; Betül Peker Cengiz; Alanna Teixeira Andrade; Adnan AyhanciThe purpose of the current study was to find out whether escin (ES) safeguarded experimental rats against cyclophosphamide (CP)-induced kidney injury. Twenty-four rats were randomly divided into four groups (n = 6). After the examination, histological and biochemical analyses were performed to assess the alterations in kidney tissue. According to histologic and biochemical analyses, renal tissue in the CP group suffered significant damage by CP. There was a significant improvement in histological damage in the group receiving CP+ES together. This suggests that ES significantly protects the kidney’s functional characteristics. The present study concludes by highlighting histological and biochemical studies to illustrate the ability of ES to cure kidney injury caused by CP and its influence on the relationship between oxidative stress, apoptosis, and renal failure. © 2024 by the authors.
