Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus

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dc.contributor.authorAsır, Fırat
dc.contributor.authorOglak, Suleyman Cemil
dc.contributor.authorKorak, Tugcan
dc.contributor.authorTas, Fatih
dc.contributor.authorYılmaz, Mehmet
dc.contributor.authorErdemcı, Fikri
dc.contributor.authorSahın, Firat
dc.date.accessioned2024-12-24T19:16:37Z
dc.date.available2024-12-24T19:16:37Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractOBJECTIVE: This study investigated vimentin expression in placentas of patients with preeclampsia and gestational diabetes mellitus (GDM). STUDY DESIGN: Placentas of preeclamptic women (n=25), women with GDM (n=25), and control cases (n=25) were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. Vimentin immune activity was analyzed in the placental sections with immunohistochemistry. Sections were imaged and analyzed under a light microscope. A semiquantitative measurement was done be- tween groups by comparing the Vimentin signal and significance was calculated. Network construction and pathway enrichment analysis were conducted using Cytoscape (v3.10.1) and ShinyGO, respectively. RESULTS: Vimentin expression was high in the placental sections of the control group. The preeclamp- sia group showed positive Vimentin expression in cytotrophoblast and syncytiotrophoblast cells and con- nective tissue of placental villi in the preeclampsia group. Vimentin expression was generally recorded as negative in placental villi, fibrinoid substances, and connective tissue cells in the GDM group. Bioinformatic analysis showed that the AGE-RAGE signaling pathway and cancer-related pathways were mainly observed in Vimentin-associated pathways, which finally activate inflammatory pathways in both preeclampsia and GDM. CONCLUSION: Vimentin expression patterns in placental tissue sections reveal nuanced regulatory mechanisms, emphasizing the need for further exploration into the functional roles of vimentin in pla- cental physiology and pathology.
dc.identifier.doi10.21613/GORM.2023.1456
dc.identifier.endpage18
dc.identifier.issn1300-4751
dc.identifier.issn2602-4918
dc.identifier.issue1
dc.identifier.startpage10
dc.identifier.trdizinid1278544
dc.identifier.urihttps://doi.org/10.21613/GORM.2023.1456
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1278544
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4509
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectVimentin
dc.subjectPreeclampsia
dc.subjectPlacenta
dc.subjectGestational diabetes mellitus
dc.titlePlacental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus
dc.typeArticle

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