The Effect of Evening Primrose (Oenothera biennis) on the Some Biochemical Parameters in Rats with Gentamicin Induced Nephrotoxicity

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dc.contributor.authorMedineli, Murat
dc.contributor.authorMert, Handan
dc.contributor.authorİrak, Kıvanç
dc.contributor.authorMert, Nihat
dc.date.accessioned2024-12-24T19:19:18Z
dc.date.available2024-12-24T19:19:18Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate the effect of evening primrose oil (EPO) on somebiochemical parameters on nephrotoxicity induced by gentamicin (GM) in rats. The rats used in thestudy were randomly divided into 4 groups each consisting of 8 rats. The control group, EPO group,GM group and GM+ EPO group. The blood samples were taken 24 hours after the 8-day trial andkidneys were removed and saved for histopathological and PGE2 analysis. The serum creatinine,BUN, calcitriol, Ca, Na, Cl, K and P analyzes were performed via autoanalyser. PGE2 analysis wasperformed in kidney tissue via ELISA. Histopathological examination of the kidney tissues wasperformed. The levels of creatinine, BUN and Cl were significantly decreased and PGE2 and Caincreased in GM + EPO compared to GM group. The changes in the biochemical parametersexamined and the histopathological findings obtained, it can be said that the EPO weakens thenephrotoxic damage caused by GM and has the protective effects on the kidney.
dc.identifier.endpage1014
dc.identifier.issn2148-127X
dc.identifier.issue6
dc.identifier.startpage1008
dc.identifier.trdizinid454973
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/454973
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5634
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Tarım - Gıda Bilim ve Teknoloji dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectTamamlayıcı ve Entegre Tıp,Endokrinoloji ve Metabolizma,Üroloji ve Nefroloji,Veterinerlik
dc.titleThe Effect of Evening Primrose (Oenothera biennis) on the Some Biochemical Parameters in Rats with Gentamicin Induced Nephrotoxicity
dc.typeArticle

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