IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)

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dc.authoridARSLAN, Mustafa/0000-0003-0796-4374
dc.contributor.authorKaya, Mustafa Oguzhan
dc.contributor.authorGulec, Ozcan
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2024-12-24T19:33:21Z
dc.date.available2024-12-24T19:33:21Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.
dc.description.sponsorshipSakarya University [2016-02-04-018]
dc.description.sponsorshipThis work was supported by Research Fund of the Sakarya University. Project Number: 2016-02-04-018.
dc.identifier.endpage3358
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue5A
dc.identifier.startpage3351
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8105
dc.identifier.volume27
dc.identifier.wosWOS:000436522400016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectParaoxonase
dc.subjectbisoxadiazole
dc.subjectsulfonamide
dc.subjectantioxidant activity
dc.subjectinhibition
dc.titleIN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)
dc.typeArticle

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