RENAL PROTECTIVE EFFECT OF GRAPE SEED EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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dc.contributor.authorSogutlu, Inci
dc.contributor.authorIrak, Kivanc
dc.contributor.authorMert, Handan
dc.contributor.authorYildirim, Serkan
dc.contributor.authorMert, Nihat
dc.date.accessioned2024-12-24T19:33:28Z
dc.date.available2024-12-24T19:33:28Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractIt was aimed to investigate the effects of grape seed extract (GSE) on structural changes that occur in renal tissues of rats with streptozocin (STZ)-induced diabetes. Rats were randomly divided into four groups (Control, Diabetes Mellitus (DM), GSE, Diabetes Mellitus+ GSE (DM + GSE) groups) each containing 8 rats. When GSE was given, the values of serum creatinine, BUN and uric acid in diabetics were decreased. Kidneys of diabetic group were found to have mild interstitial nephritis, tubular dilatation, hydropic degeneration, clotting necrosis in the tubular epithelium, dilatation in glomerulus and Bowman capsule, and hyperemia in glomerular capillaries. In the DM + GSE group, the glomeruli were normal, but hydropic degeneration was observed in some of the tubule epithelium. Only a few 8-OhDG positive cells were detected in tubule epithelium in the diabetes + grape seed group. The administration of GSE to diabetic patients helped to heal the deteriorated of kidney condition and DNA damage.
dc.identifier.endpage1599
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue2
dc.identifier.startpage1592
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8136
dc.identifier.volume31
dc.identifier.wosWOS:000760842200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectDiabetes mellitus
dc.subjectgrape seed extract
dc.subjectcreatinine
dc.subjecthistopathology
dc.subjectimmunohistochemical alterations
dc.titleRENAL PROTECTIVE EFFECT OF GRAPE SEED EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
dc.typeArticle

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