Immunotherapeutic and Cell-Protective Effects of Probiotic Kefir on Cyclophosphamide induced Nephrotoxicity and Urotoxicity in Rats

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dc.contributor.authorYıldız, Songül Çetik
dc.contributor.authorDemir, Cemil
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorIrmak, Halit
dc.contributor.authorCengiz, Betül Peker
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:18:05Z
dc.date.available2024-12-24T19:18:05Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractTo evaluate kefir, a naturally occurring fermented dairy product, with pharmacological and therapeutic qualities including antioxidant, anti-apoptotic, and anti-inflammatory effects against cyclophosphamide (CP)-induced hemorrhagic cystitis and nephrotoxicity in rats. For this purpose, experimental rats were divided into 6 groups; control (Group 1), 150 mg/kg CP (Group 2), 5 mg/kg kefir (Group 3), l0 mg/kg kefir (Group 4), 5 mg/kg kefir+150 CP (Group 5), l0 mg/kg kefir+150 CP (Group 6). Since there was no difference in kefirs fermented on different days, kefirs from the 1st, 2nd, and 3rd days were mixed and given to the rats for 12 days, while CP was given as an only dose and i.p. on the 12th day of the experiment. Histologic evaluations revealed that CP caused toxicity in kidney and bladder. On the other hand, biochemical evaluations showed a significant increase in serum blood urea nitrogen (BUN) and creatinine (Cre) levels, which are tissue toxicity markers, and a significant decrease in catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels, which are intracellular antioxidant system markers, in the CP-treated experimental group. However, all values were reversed as a result of kefir (5 and 10 mg/kg) treatment. These results showed that kefir is an effective protective agent against CP-induced hemorrhagic cystitis and nephrotoxicity.
dc.identifier.doi10.35414/akufemubid.1424423
dc.identifier.endpage1284
dc.identifier.issn2149-3367
dc.identifier.issue6
dc.identifier.startpage1275
dc.identifier.trdizinid1283579
dc.identifier.urihttps://doi.org/10.35414/akufemubid.1424423
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1283579
dc.identifier.urihttps://hdl.handle.net/20.500.12604/4930
dc.identifier.volume24
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAfyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectKefir
dc.subjectNephrotoxicity
dc.subjectCyclophosphamide
dc.subjectImmunotherapy
dc.subjectHemorrhagic cystitis
dc.titleImmunotherapeutic and Cell-Protective Effects of Probiotic Kefir on Cyclophosphamide induced Nephrotoxicity and Urotoxicity in Rats
dc.typeArticle

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